Persistence of human parvovirus B19 in human tissues

被引:115
作者
Söderlund-Venermo, M
Hokynar, K
Nieminen, J
Rautakorpi, H
Hedman, K
机构
[1] Univ Helsinki, Dept Virol, Haartman Inst, FIN-00014 Helsinki, Finland
[2] Univ Helsinki, Cent Hosp, FIN-00290 Helsinki, Finland
来源
PATHOLOGIE BIOLOGIE | 2002年 / 50卷 / 05期
关键词
chronic infection; disease association; DNA persistence; erythrovirus B19; polymerase chain reaction (PCR);
D O I
10.1016/S0369-8114(02)00307-3
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Human parvovirus B19 infection causes various clinical symptoms, such as rash, arthropathy, anemias and fetal death, but it can also remain asymptomatic. The arthropathies and anemias can become chronic for several years, not infrequently resembling autoimmune syndromes. B19 replicates only in red blood cell precursors of bone marrow or fetal liver, resulting in high-titred short-lived viremia, but viral DNA is detectable also in cells of several other types. Recently B19 DNA has been found, by very sensitive amplification tests, in certain tissues not only of symptomatic but also of healthy individuals for several years or decades after B19 infection. The mere presence of 1319 DNA in these tissues of a symptomatic patient (e.g. joints in chronic arthritis or skin in dermatomyositis) thereby does not prove that the present disease is caused by B19. The diagnosis has to be verified by other innovative means. How and why viral DNA persists in the tissues of healthy individuals is under investigation. (C) 2002 Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码:307 / 316
页数:10
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