Genetics of bipolar disorder: successful start to a long journey

被引：106

作者：

Craddock, Nick ^{[1
]}

Sklar, Pamela ^{[2
,3
,4
,5
,6
,7
,8
]}

机构：

[1] Cardiff Univ, Sch Med, Dept Psychol Med, Cardiff CF14 4XN, S Glam, Wales

[2] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA

[3] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA

[5] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

[6] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA

[7] Broad Inst Harvard, Stanley Ctr Psychiat Res, Cambridge, MA 02142 USA

[8] MIT, Cambridge, MA 02142 USA

来源：

TRENDS IN GENETICS | 2009年 / 25卷 / 02期

关键词：

GENOME-WIDE ASSOCIATION; FAMILY-BASED ASSOCIATION; AMINO-ACID OXIDASE; CANDIDATE GENES; SCHIZOAFFECTIVE DISORDER; SUSCEPTIBILITY LOCI; SPECTRUM DISORDERS; SUGGESTIVE LINKAGE; PUTATIVE LOCI; SCHIZOPHRENIA;

D O I：

10.1016/j.tig.2008.12.002

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Family and twin studies attest to the importance of genetic factors influencing susceptibility to bipolar disorder and to its genetic and phenotypic complexity. Although linkage and candidate gene association studies have repeatedly implicated some chromosome regions and certain genes, they have not produced the level of unambiguous support required to confirm the involvement of any specific gene or sequence variant in the pathogenesis of bipolar disorder. However, strong associations have recently been reported in meta-analyses of genome-wide association studies and the systematic study of structural variation is ongoing. These findings indicate that the study of large, phenotypically well-characterized samples will make an important contribution to delineating the etiology and pathogenesis of bipolar disorder and thereby pave the way for major improvements in clinical management.

引用

页码：99 / 105

页数：7

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