Antimicrobial activity of chitosan N-betainates

被引：93

作者：

Holappa, Jukka

Hjalmarsdottir, Martha

Masson, Mar

Runarsson, Ogmundur

Asplund, Tomas

Soininen, Pasi

Nevalainen, Tapio

Jarvinen, Tomi

机构：

[1] Univ Kuopio, Dept Pharmaceut Chem, FIN-70211 Kuopio, Finland

[2] Reykjavik Univ, Sch Sci & Engn, Dept Biomed Sci, IS-110 Reykjavik, Iceland

[3] Univ Iceland, Fac Pharm, IS-107 Reykjavik, Iceland

[4] Ciba Specialty Chem Oy, Water & Paper Treatment, Surface & Coatings R&D, FIN-21201 Raisio, Finland

[5] Univ Kuopio, Dept Chem, FIN-70211 Kuopio, Finland

来源：

CARBOHYDRATE POLYMERS | 2006年 / 65卷 / 01期

基金：

芬兰科学院;

关键词：

chitosan; synthesis; quaternary; water-soluble; antimicrobial;

D O I：

10.1016/j.carbpol.2005.11.041

中图分类号：

O69 [应用化学];

学科分类号：

081704 [应用化学];

摘要：

The effect of degree of substitution on the antimicrobial activity of water-soluble quaternary chitosan N-betainates was determined against Escherichia coli and Staphylococcus aureus. Chitosan N-betainates showed low antimicrobial activity in neutral conditions and the glucosamine N-betainate prepared as a reference compound showed low activity also in acidic conditions. However, the antimicrobial activity increased with decreasing degrees of substitution in acidic conditions (pH 5.5), which suggests that for efficient antimicrobial action, the positive charge should be situated in the amino group of chitosan, rather than in the quaternary substituent. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：114 / 118

页数：5

共 29 条

[1]

Factors affecting the susceptibility of Staphylococcus aureus CCRC 12657 to water soluble lactose chitosan derivative [J].