Amnesia or retrieval deficit? Implications of a molecular approach to the question of reconsolidation

被引:40
作者
Miller, Courtney A. [1 ]
Sweatt, J. David [1 ]
机构
[1] Univ Alabama Birmingham, Dept Neurobiol, Birmingham, AL 35294 USA
关键词
D O I
10.1101/lm.304606
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
Post-retrieval interference with a memory has uncovered a phenomenon known to the field as reconsoliclation. In this article, we will review the specific molecular mechanisms that have been implicated in reconsoliclation. As a result of numerous studies over the past five years, it can now be said with a fair amount of certainty that reconsoliclation is not a recapitulation of the mechanisms underlying consolidation, despite what the term. reconsolidation" may suggest. Therefore, in addition to reviewing the known mechanisms of reconsoliclation, we will propose that two experimental approaches involving the targeting of specific molecular mechanisms, and the Study of these mechanisms during retrieval, may serve useful to the field as it is now able to advance beyond comparisons between consolidation and reconsoliclation.
引用
收藏
页码:498 / 505
页数:8
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