Overview of stem cell therapy for Crohn's disease

被引：36

作者：

Dryden, Gerald Wayne ^{[1
]}

机构：

[1] Univ Louisville, Div Gastroenterol, Dept Med, Louisville, KY 40202 USA

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2009年 / 9卷 / 07期

关键词：

Crohn's disease; mesenchymal stem cell therapy; regional enteritis; stem cell therapy; MAINTENANCE THERAPY; CERTOLIZUMAB PEGOL; ADALIMUMAB; INHIBIT; TRANSPLANTATION; LYMPHOCYTE; INFLIXIMAB; NATALIZUMAB; INDUCTION; RESPONSES;

D O I：

10.1517/14712590902956615

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Background: Crohn's disease (CD) therapy is rapidly evolving. Recent and ongoing clinical trials using immunologically active stem cells (SC) for the treatment of CD demonstrate the potential for this novel therapy to induce complete and long-lasting remission of symptoms in settings where 'standard' therapies have been unsuccessful. Objective/methods: This review of SC, including mesenchymal stem cell (MSC) therapy for CD discusses how the immunological effects of MSC may correct some of the pathophysiological defects underpinning CD, and examines the latest clinical trial data providing evidence of their efficacy in the treatment of Crohn's disease. Results/conclusions: Given the beneficial effects on mucosal healing seen in animal models of inflammation and results from early clinical trials, MSC may serve as a candidate therapy for patients who have failed to respond to biological therapy.

引用

页码：841 / 847

页数：7

共 50 条

[1]

Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells [J].

Abe, Kazumichi ;

Nguyen, Kim Phung ;

Fine, Sean D. ;

Mo, Ji-Hun ;

Shen, Carol ;

Shenouda, Steve ;

Corr, Maripat ;

Jung, Steffen ;

Lee, Jongdae ;

Eckmann, Lars ;

Raz, Eyal .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (43) :17022-17027

[2]

Human mesenchymal stem cells modulate allogeneic immune cell responses [J].

Aggarwal, S ;

Pittenger, MF .

BLOOD, 2005, 105 (04) :1815-1822

[3]

Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient [J].

Amariglio, Ninette ;

Hirshberg, Abraham ;

Scheithauer, Bernd W. ;

Cohen, Yoram ;

Loewenthal, Ron ;

Trakhtenbrot, Luba ;

Paz, Nurit ;

Koren-Michowitz, Maya ;

Waldman, Dalia ;

Leider-Trejo, Leonor ;

Toren, Amos ;

Constantini, Shlomi ;

Rechavi, Gideon .

PLOS MEDICINE, 2009, 6 (02) :221-231

[4]

Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo [J].

Bartholomew, A ;

Sturgeon, C ;

Siatskas, M ;

Ferrer, K ;

McIntosh, K ;

Patil, S ;

Hardy, W ;

Devine, S ;

Ucker, D ;

Deans, R ;

Moseley, A ;

Hoffman, R .

EXPERIMENTAL HEMATOLOGY, 2002, 30 (01) :42-48

[5]

MESENCHYMAL STEM-CELLS [J].

CAPLAN, AI .

JOURNAL OF ORTHOPAEDIC RESEARCH, 1991, 9 (05) :641-650

[6]

Autologous haematopoietic stem cell transplantation without CD34+ cell selection in refractory Crohn's disease [J].

Cassinotti, A. ;

Annaloro, C. ;

Ardizzone, S. ;

Onida, F. ;

Della Volpe, A. ;

Clerici, M. ;

Usardi, P. ;

Greco, S. ;

Maconi, G. ;

Porro, G. Bianchi ;

Deliliers, G. Lambertenghi .

GUT, 2008, 57 (02) :211-217

[7]

Mesenchymal stem cells home to injured tissues when co-infused with hematopoietic cells to treat a radiation-induced multi-organ failure syndrome [J].

Chapel, A ;

Bertho, JM ;

Bensidhoum, M ;

Fouillard, L ;

Young, RG ;

Frick, J ;

Demarquay, C ;

Cuvelier, F ;

Mathieu, E ;

Trompier, F ;

Dudoignon, N ;

Germain, C ;

Mazurier, C ;

Aigueperse, J ;

Borneman, J ;

Gorin, NC ;

Gourmelon, P ;

Thierry, D .

JOURNAL OF GENE MEDICINE, 2003, 5 (12) :1028-1038

[8]

Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: The CHARM trial [J].

Colombel, Jean-Frederic ;

Sandborn, William J. ;

Rutgeerts, Paul ;

Enns, Robert ;

Hanauer, Stephen B. ;

Panaccione, Remo ;

Schreiber, Stefan ;

Byczkowski, Dan ;

Li, Ju ;

Kent, Jeffrey D. ;

Pollack, Paul F. .

GASTROENTEROLOGY, 2007, 132 (01) :52-65

[9]

Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease:: an open randomised trial [J].

D'Haens, Geert ;

Baert, Filip ;

van Assche, Gert ;

Caenepeel, Philip ;

Vergauwe, Philippe ;

Tuynman, Hans ;

De Vos, Martine ;

van Deventer, Sander ;

Stitt, Larry ;

Donner, Allan ;

Vermeire, Severine ;

Van De Mierop, Frank J. ;

Coche, Jean-Charles R. ;

van der Woude, Janneke ;

Ochsenkuehn, Thomas ;

van Bodegraven, Ad A. ;

van Hootegem, Philippe P. ;

Lambrecht, Guy L. ;

Mana, Fazia ;

Rutgeerts, Paul ;

Feagan, Brian G. ;

Hommes, Daniel .

LANCET, 2008, 371 (9613) :660-667

[10]

Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates [J].

Devine, SM ;

Cobbs, C ;

Jennings, M ;

Bartholomew, A ;

Hoffman, R .

BLOOD, 2003, 101 (08) :2999-3001

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