Different cytokines induce surface lymphotoxin-αβ on IL-7 receptor-α cells that differentially engender lymph nodes and Peyer's patches

被引：199

作者：

Yoshida, H ^{[1
]}

Naito, A

Inoue, J

Satoh, M

Santee-Cooper, SM

Ware, CF

Togawa, A

Nishikawa, S

机构：

[1] RIKEN, Yokohama Inst, Div Immunogenet, Res Ctr Allergy & Immunol, Yokohama, Kanagawa 2300045, Japan

[2] Kyoto Univ, Grad Sch Med, Dept Mol Genet, Sakyo Ku, Kyoto 6068507, Japan

[3] Univ Tokyo, Inst Med Sci, Div Oncol, Minato Ku, Tokyo 1088639, Japan

[4] Univ Tokyo, Inst Med Sci, Dept Canc Biol, Div Cellular & Mol Biol,Minato Ku, Tokyo 1088639, Japan

[5] La Jolla Inst Allergy & Immunol, Div Mol Immunol, San Diego, CA 92121 USA

来源：

IMMUNITY | 2002年 / 17卷 / 06期

关键词：

D O I：

10.1016/S1074-7613(02)00479-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The formation of lymph nodes (LN) and Peyer's patches (PP) can be distinguished by the requirement of RANK for LN but not IL-7Ralpha, which is essential for PP development. However, lymphotoxin-alphabeta (LTalphabeta) signaling is required for both organs. The cellular basis underlying this dichotomy was revealed by the finding that the fetal IL-7Ralpha(+) population responded equally well to IL-7 and RANKL to express LTalphabeta. IL-7Ralpha(+) cells harvested from TRAF6(-/-) embryos expressed I-Tap in response to IL-7 but not RANKL, demonstrating that the RANK-TRAF6 signaling pathway regulates LTalphabeta expression in LN but not in PP. Soluble IL-7 administered to TRAF6(-/-) embryos was sufficient to restore LN genesis indicating the functional similarities of the IL-7Ralpha(+) inducer cells for LN and PP genesis.

引用

页码：823 / 833

页数：11

共 47 条

[1] Three distinctive steps in Peyer's patch formation of murine embryo [J].