Deciphering the underlying genetic and epignetic events leading to gastric carcinogenesis

被引：99

作者：

Vogiatzi, Paraskevi

Vindigni, Carla

Roviello, Franco

Renieri, Alessandra

Giordano, Antonio

机构：

[1] Temple Univ, Sbarro Inst Canc Res & Mol Med, Coll Sci & Technol, Ctr Biotechnol, Philadelphia, PA 19122 USA

[2] Univ Siena, Dept Mol Biol, I-53100 Siena, Italy

[3] Univ Siena, Dept Human Pathol & Oncol, I-53100 Siena, Italy

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2007年 / 211卷 / 02期

关键词：

D O I：

10.1002/jcp.20982

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Gastric cancer is a common aggressive malignancy. Although its incidence shows considerable variation among different countries, gastric cancer is still a major health problem worldwide. The causes of stomach cancer are not completely understood. What is clear is that gastric cancer is a multi-stage process involving genetic and epigenetic factors. This review is an in-depth study of the known genetic and epigenetic processes in the development of this tumor, and delineates possible approaches in gene and epigenetic therapy.

引用

页码：287 / 295

页数：9

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