Type IV secretion and Brucella virulence

被引：80

作者：

Boschiroli, ML

Ouahrani-Bettache, S

Foulongne, V

Michaux-Charachon, S

Bourg, G

Allardet-Servent, A

Cazevieille, C

Lavigne, JP

Liautard, JP

Ramuz, M

O'Callaghan, D

机构：

[1] Fac Med, INSERM U431, F-30900 Nimes, France

[2] INSERM U431, F-34095 Montpellier, France

来源：

VETERINARY MICROBIOLOGY | 2002年 / 90卷 / 1-4期

关键词：

VirB; TFSS; VirB12; quorum sensing; phagosome acidification; Brucella;

D O I：

10.1016/S0378-1135(02)00219-5

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The type IV secretion system, encoded by the virB region, is a key virulence factor for Brucella. The 12 genes of the region form an operon that is specifically induced by phagosome acidification in cells after phagocytosis. We speculate that the system serves to secrete unknown effector molecules, which allow Brucella to pervert the host cell endosomal pathways and to create a novel intracellular compartment in which it can replicate. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：341 / 348

页数：8

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