Apolipoprotein E allele-dependent antioxidant activity in brains with Alzheimer's disease

被引：62

作者：

Tamaoka, A

Miyatake, F

Matsuno, S

Ishii, K

Nagase, S

Sahara, N

Ono, S

Mori, H

Wakabayashi, K

Tsuji, S

Takahashi, H

Shoji, S

机构：

[1] Univ Tsukuba, Inst Clin Med, Dept Neurol, Tsukuba, Ibaraki 3050006, Japan

[2] Univ Tsukuba, Inst Clin Med, Dept Nephrol, Tsukuba, Ibaraki 3050006, Japan

[3] Osaka City Univ, Sch Med, Dept Neurosci, Osaka, Japan

[4] Niigata Univ, Brain Res Inst, Dept Neurol, Niigata 951, Japan

[5] Niigata Univ, Brain Res Inst, Dept Pathol, Niigata 951, Japan

[6] Teikyo Univ, Sch Med, Ichihara Hosp, Dept Neurol, Chiba, Japan

来源：

NEUROLOGY | 2000年 / 54卷 / 12期

关键词：

AD; APOE; lipid peroxidation; thiobarbituric acid-reactive substances; oxidative stress;

D O I：

10.1212/WNL.54.12.2319

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Thiobarbituric acid-reactive substances (TBARS), an index of lipid peroxidation, were assayed in postmortem brain. Basal TBARS levels were increased and oxidative stimulation produced more TBARS in AD relative to control brains. In addition, apolipoprotein E isoforms showed differing antioxidant activities, with E2 > E3 > E4, suggesting that the lowest antioxidant activity of E4 could contribute to its association with AD.

引用

页码：2319 / 2321

页数：3

共 10 条

[1] BASAL LIPID-PEROXIDATION IN SUBSTANTIA NIGRA IS INCREASED IN PARKINSONS-DISEASE [J].