Defining the role of laminin-332 in carcinoma

被引：72

作者：

Guess, Cherise M. ^{[1
,2
]}

Quaranta, Vito ^{[1
,3
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Canc Biol, Nashville, TN 37232 USA

[2] Meharry Med Coll, Dept Microbial Pathogenesis & Immune Reponse, Nashville, TN 37208 USA

[3] Vanderbilt Univ, Med Ctr, Vanderbilt Integrat Canc Biol Ctr, Nashville, TN 37232 USA

来源：

MATRIX BIOLOGY | 2009年 / 28卷 / 08期

关键词：

Laminin-332; Cancer; Invasion; Prognosis; Extracellular matrix; SQUAMOUS-CELL CARCINOMA; GAMMA-2 CHAIN EXPRESSION; JUNCTIONAL EPIDERMOLYSIS-BULLOSA; EPIDERMAL-GROWTH-FACTOR; ABERRANT PROMOTER METHYLATION; CONGENITAL MUSCULAR-DYSTROPHY; FACTOR RECEPTOR EXPRESSION; MONOCLONAL-ANTIBODY GB3; INVADING CANCER-CELLS; BETA-3; CHAIN;

D O I：

10.1016/j.matbio.2009.07.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The deadly feature of cancer, metastasis, requires invasion of cells through basement membranes (BM), which normally act as barriers between tissue compartments. In the case of many epithelially-derived cancers (carcinomas), laminin-332 (Ln-332) is a key component of the BM barrier. This review provides a historical examination of Ln-332 from its discovery through identification of its functions in BM and possible role in carcinomas. Current understanding points to distinct roles for the three Ln-332 subunits (alpha 3, beta 3, gamma 2) in cell adhesion, extracellular matrix stability, and cell signaling processes in cancer. Given the large number of studies linking Ln-332 gamma 2 subunit with cancer prognosis, particular attention is given to the crucial role of this subunit in cancer invasion and to the unanswered questions in this area. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：445 / 455

页数：11

共 203 条

[1] HERLITZS JUNCTIONAL EPIDERMOLYSIS-BULLOSA IS LINKED TO MUTATIONS IN THE GENE (LAMC2) FOR THE GAMMA-2 SUBUNIT OF NICEIN/KALININ (LAMININ-5) [J].