Assessment of pain in herpes zoster: Lessons learned from antiviral trials

被引:60
作者
Dworkin, RH
Carrington, D
Cunningham, A
Kost, RG
Levin, MJ
McKendrick, MW
Oxman, MN
Rentier, B
Schmader, KE
Tappeiner, G
Wassilew, SW
Whitley, RJ
机构
[1] ST GEORGE HOSP, LONDON, ENGLAND
[2] WESTMEAD HOSP, DEPT VIROL, WESTMEAD, NSW 2145, AUSTRALIA
[3] NIH, BETHESDA, MD 20892 USA
[4] UNIV COLORADO, HLTH SCI CTR, DENVER, CO USA
[5] ROYAL HALLAMSHIRE HOSP, SHEFFIELD S10 2JF, S YORKSHIRE, ENGLAND
[6] UNIV CALIF SAN DIEGO, LA JOLLA, CA 92093 USA
[7] UNIV LIEGE, LIEGE, BELGIUM
[8] DUKE UNIV, MED CTR, DURHAM, NC USA
[9] UNIV VIENNA, DERMATOL KLIN, ALLGEMEINES KRANKENHAUS WIEN, VIENNA, AUSTRIA
[10] KLINIKUM KREFELD, DERMATOL KLIN, KREFELD, GERMANY
[11] UNIV ALABAMA, BIRMINGHAM, AL USA
关键词
clinical trials; herpes zoster; pain analyses; post-herpetic neuralgia; primary endpoint; zoster-associated pain;
D O I
10.1016/S0166-3542(96)01007-8
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Pain typically accompanies acute herpes tester and, in a proportion of patients, it persists well beyond rash healing. Pain must therefore be analyzed in trials of antiviral agents in herpes tester, but different methods have been used to analyze pain in recent published trials. These reports are reviewed and their methodological strengths and weaknesses examined. Based on this review? recommendations for the design and analysis of future trials of antiviral agents in herpes tester are proposed. The principal recommendation is that antiviral efficacy should be evaluated both by distinguishing post-herpetic neuralgia from acute pain and by considering pain as a continuum. The primary endpoint should address both the prevalence and duration of post-herpetic neuralgia and should be examined in those patients who have post-herpetic neuralgia. Adopting the proposed recommendations in design and analysis of future trials should facilitate comparison across trials of the efficacy of antiviral agents in the treatment of herpes tester. Copyright (C) 1997 Elsevier Science B.V.
引用
收藏
页码:73 / 85
页数:13
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