Principles of miRNA-Target Regulation in Metazoan Models

被引：26

作者：

Doxakis, Epaminondas ^{[1
]}

机构：

[1] Acad Athens, Biomed Res Fdn, Basic Neurosci Div, Athens 11527, Greece

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 08期

关键词：

miR; miR biogenesis; miR targets; miR turnover; isomiR; ceRNA; RNA-BINDING PROTEIN; MICRORNA EXPRESSION PROFILES; 3' UNTRANSLATED REGIONS; EMBRYONIC STEM-CELLS; MESSENGER-RNAS; POLYMERASE-III; STRAND SELECTION; GENE-EXPRESSION; TRANSCRIPTIONAL ACTIVATION; MICROPROCESSOR COMPLEX;

D O I：

10.3390/ijms140816280

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

MicroRNAs (miRs) are key post-transcriptional regulators that silence gene expression by direct base pairing to target sites of RNAs. They have a wide variety of tissue expression patterns and are differentially expressed during development and disease. Their activity and abundance is subject to various levels of control ranging from transcription and biogenesis to miR response elements on RNAs, target cellular levels and miR turnover. This review summarizes and discusses current knowledge on the regulation of miR activity and concludes with novel non-canonical functions that have recently emerged.

引用

页码：16280 / 16302

页数：23

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