Heme oxygenase 1 is associated with ischemic preconditioning-induced protection against brain ischemia

被引：69

作者：

Zeynalov, Emil ^{[1
]}

Shah, Zahoor A. ^{[1
]}

Li, Rung-chi ^{[1
]}

Dore, Sylvain ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21205 USA

来源：

NEUROBIOLOGY OF DISEASE | 2009年 / 35卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Heme oxygenase; Ischemic preconditioning; Middle cerebral artery occlusion; Neuroprotection; Permanent middle cerebral artery occlusion; NEURONAL NITRIC-OXIDE; EXPRESSION; HEME-OXYGENASE-1; REPERFUSION; TOLERANCE; INJURY; LIVER; RAT; DESENSITIZATION; INFLAMMATION;

D O I：

10.1016/j.nbd.2009.05.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ischemic preconditioning (IPC) protects brain against ischemic injury by activating specific mechanisms. Our goal was to determine if the inducible heme oxygenase 1 (HO1) is required for such protection. IPC before transient or permanent ischemia reduced cortical infarct volumes by 57.4% and 33.9%, respectively at 48 h in wildtype adult mice. Interestingly, IPC failed to protect the HO1 gene deleted mice against permanent ischemic brain injury. IPC also resulted in a significant increase in HO1 protein levels in the brain and correlated with reduced neurological deficits after permanent and transient brain ischemia. Our study demonstrates that neuroprotective effects of IPC are at least partially mediated via HO1. Elucidating the physiological/cellular role by which HO1 is protective against brain ischemia may aid the development of selective drugs to treat stroke and its associated neurological disorders. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：264 / 269

页数：6

共 34 条

[1] Heme oxygenase-1 protects brain from acute excitotoxicity [J].

Ahmad, A. S. ;

Zhuang, H. ;

Dore, S. .

NEUROSCIENCE, 2006, 141 (04) :1703-1708

[2] Rapid cerebral ischemic preconditioning in mice deficient in endothelial and neuronal nitric oxide synthases [J].

Atochin, DN ;

Clark, J ;

Demchenko, IT ;

Moskowitz, MA ;

Huang, PL .

STROKE, 2003, 34 (05) :1299-1303

[3] ENDOTHELIAL-CELL HEME UPTAKE FROM HEME-PROTEINS - INDUCTION OF SENSITIZATION AND DESENSITIZATION TO OXIDANT DAMAGE [J].

BALLA, J ;

JACOB, HS ;

BALLA, G ;

NATH, K ;

EATON, JW ;

VERCELLOTTI, GM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (20) :9285-9289

[4]

Bergeron M, 1997, J CEREBR BLOOD F MET, V17, P647

[5] STRESS-INDUCED 5-HT1A, RECEPTOR DESENSITIZATION - PROTECTIVE EFFECTS OF GINKGO-BILOBA EXTRACT (EGB-761) [J].

BOLANOSJIMENEZ, F ;

DECASTRO, RM ;

SARHAN, H ;

PRUDHOMME, N ;

DRIEU, K ;

FILLION, G .

FUNDAMENTAL & CLINICAL PHARMACOLOGY, 1995, 9 (02) :169-174

[6] Heme oxygenase-1-derived carbon monoxide requires the activation of transcription factor NF-κB to protect endothelial cells from tumor necrosis factor-α-mediated apoptosis [J].

Brouard, S ;

Berberat, PO ;

Tobiasch, E ;

Seldon, MP ;

Bach, FH ;

Soares, MP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (20) :17950-17961

[7] Obligatory role of inducible nitric oxide synthase in ischemic preconditioning [J].

Cho, S ;

Park, EM ;

Zhou, P ;

Frys, K ;

Ross, ME ;

Iadecola, C .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2005, 25 (04) :493-501

[8] Astroglial cytoprotection by erythropoietin pre-conditioning: implications for ischemic and degenerative CNS disorders [J].

Diaz, Z ;

Assaraf, MI ;

Miller, WH ;

Schipper, HM .

JOURNAL OF NEUROCHEMISTRY, 2005, 93 (02) :392-402

[9] Role of heme oxygenase in the protection afforded skeletal muscle during ischemic tolerance [J].

Dungey, AA ;

Badhwar, A ;

Bihari, A ;

Kvietys, PR ;

Harris, KA ;

Forbes, TL ;

Potter, RF .

MICROCIRCULATION, 2006, 13 (02) :71-79

[10] Haem oxygenase-1 prevents cell death by regulating cellular iron [J].

Ferris, CD ;

Jaffrey, SR ;

Sawa, A ;

Takahashi, M ;

Brady, SD ;

Barrow, RK ;

Tysoe, SA ;

Wolosker, H ;

Barañano, DE ;

Doré, S ;

Poss, KD ;

Snyder, SH .

NATURE CELL BIOLOGY, 1999, 1 (03) :152-157

← 1 2 3 4 →