Sprouty and cancer: The first terms report

被引：71

作者：

Lo, Ting Ling

Fong, Chee Wai

Yusoff, Permeen

Mckie, Arthur B.

Chua, Mei-Sze

Leung, Hing Y.

Guy, Graeme R.

机构：

[1] Inst Mol & Cell Biol, Signal Transduct Lab, Proteos 138673, Singapore

[2] Univ Newcastle, Sch Med, Urol Res Grp, No Inst Canc Res, Newcastle Upon Tyne NE2 4AD, Tyne & Wear, England

[3] Stanford Univ, Dept Surg, Stanford, CA 94305 USA

来源：

CANCER LETTERS | 2006年 / 242卷 / 02期

基金：

英国医学研究理事会;

关键词：

Sprouty; cancer; tumour suppressor; tumour marker; Ras/Erk pathway; gene deregulation;

D O I：

10.1016/j.canlet.2005.12.032

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Ras/Erk signaling pathway has a central role in development of multi-cellular organisms as well as in signal transmission in the mature individual. Recently, a family of genes, designated Sprouty, induced by the Ras/Erk pathway was found to specify proteins that inhibited the upstream pathway. Being in a position that is likely to control well-characterized oncogene products suggested that the expression levels of the Sprouty genes may be relevant in human carcinogenesis. Early data on the deregulation of Sprouty expression in breast, prostate and liver cancers is discussed along with the notion that some of them might have potential as tumour markers or that the derived proteins may act as tumour suppressors. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：141 / 150

页数：10

共 52 条

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