Phosphorylation of L1-type cell-adhesion molecules - ankyrins away!

被引：16

作者：

Nagaraj, Kakanahalli ^{[1
]}

Hortsch, Michael ^{[1
]}

机构：

[1] Univ Michigan, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2006年 / 31卷 / 10期

关键词：

D O I：

10.1016/j.tibs.2006.07.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neural cell-adhesion molecules (CAMs) are powerful initiators of neurite outgrowth during neural differentiation. In addition, their interactions with cytoskeletal components are often conserved and highly regulated. How these two aspects of neural CAM function relate to each other is not well understood. However, a recent publication from the Felsenfeld laboratory (http:// www.mssm.edu/labs/felsenfeld) fills a gap in our knowledge of how the interaction of L1-type CAMs with the membrane skeleton adaptor protein ankyrin is severed by phosphorylation and suggests a feedback mechanism whereby the neurite-stimulating activity of L1-CAM is inversely connected to its cytoskeleton binding.

引用

页码：544 / 546

页数：3

共 20 条

[1] Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at Purkinje axon initial segment [J].

Ango, F ;

di Cristo, G ;

Higashiyama, H ;

Bennett, V ;

Wu, P ;

Huang, ZJ .

CELL, 2004, 119 (02) :257-272

[2] Ankyrins and cellular targeting of diverse membrane proteins to physiological sites [J].

Bennett, V ;

Chen, LS .

CURRENT OPINION IN CELL BIOLOGY, 2001, 13 (01) :61-67

[3] LAD-1, the Caenorhabditis elegans L1CAM homologue, participates in embryonic and gonadal morphogenesis and is a substrate for fibroblast growth factor receptor pathway-dependent phosphotyrosine-based signaling [J].

Chen, LS ;

Ong, B ;

Bennett, V .

JOURNAL OF CELL BIOLOGY, 2001, 154 (04) :841-855

[4] Neuroglian-mediated cell adhesion induces assembly of the membrane skeleton at cell contact sites [J].

Dubreuil, RR ;

MacVicar, G ;

Dissanayake, S ;

Liu, CH ;

Homer, D ;

Hortsch, M .

JOURNAL OF CELL BIOLOGY, 1996, 133 (03) :647-655

[5] The EGF and FGF receptors mediate neuroglian function to control growth cone decisions during sensory axon guidance in Drosophila [J].

García-Alonso, L ;

Romani, S ;

Jiménez, F .

NEURON, 2000, 28 (03) :741-752

[6] Tyrosine phosphorylation at a site highly conserved in the L1 family of cell adhesion molecules abolishes ankyrin binding and increases lateral mobility of neurofascin [J].

Garver, TD ;

Ren, Q ;

Tuvia, S ;

Bennett, V .

JOURNAL OF CELL BIOLOGY, 1997, 137 (03) :703-714

[7] Ankyrin binding mediates L1CAM interactions with static components of the cytoskeleton and inhibits retrograde movement of L1CAM on the cell surface [J].

Gil, OD ;

Sakurai, T ;

Bradley, AE ;

Fink, MY ;

Cassella, MR ;

Kuo, JA ;

Felsenfeld, DP .

JOURNAL OF CELL BIOLOGY, 2003, 162 (04) :719-730

[8] A conserved role of Drosophila neuroglian and human L1-CAM in central-synapse formation [J].

Godenschwege, TA ;

Kristiansen, LV ;

Uthaman, SB ;

Hortsch, M ;

Murphey, RK .

CURRENT BIOLOGY, 2006, 16 (01) :12-23

[9] Structural requirements for outside-in and inside-out signaling by Drosophila neuroglian, a member of the L1 family of cell adhesion molecules [J].

Hortsch, M ;

Homer, D ;

Malhotra, JD ;

Chang, S ;

Frankel, J ;

Jefford, G ;

Dubreuil, RR .

JOURNAL OF CELL BIOLOGY, 1998, 142 (01) :251-261

[10] Structural and functional evolution of the L1 family: Are four adhesion molecules better than one? [J].

Hortsch, M .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2000, 15 (01) :1-10

← 1 2 →