Positive selection of thymocytes bearing alpha beta T cell receptors

被引：101

作者：

Marrack, P

Kappler, J

机构：

[1] UNIV COLORADO,HLTH SCI CTR,DEPT BIOCHEM,DENVER,CO 80206

[2] UNIV COLORADO,HLTH SCI CTR,DEPT BIOPHYS & GENET,DENVER,CO 80206

[3] UNIV COLORADO,HLTH SCI CTR,DEPT IMMUNOL,DENVER,CO 80206

[4] UNIV COLORADO,HLTH SCI CTR,DEPT MED,DENVER,CO 80206

来源：

CURRENT OPINION IN IMMUNOLOGY | 1997年 / 9卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(97)80144-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The past year has been marked by the application of new technologies to study thymocyte development. These studies have shown that positive selection affects a surprisingly large proportion of thymocytes, and now are beginning to investigate the affinities/avidities of the reactions involved. The lengthy controversy over how thymocytes decide whether to express CD4 or CD8 has taken a new turn with the discovery that levels of expression of the fate-determining protein Notch may affect the decision.

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页码：250 / 255

页数：6

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