Unexpected tandem Sonogashira-carbopalladation-Sonogashira coupling reaction of benzyl halides with terminal alkynes: A novel four-component domino sequence to highly substituted enynes

被引：22

作者：

Pottier, LR ^{[1
]}

Peyrat, JF ^{[1
]}

Alami, M ^{[1
]}

Brion, JD ^{[1
]}

机构：

[1] Univ Paris 11, Fac Pharm, CNRS, UMR 8076,BioCIS,Lab Chim Therapeut, F-92296 Chatenay Malabry, France

来源：

SYNLETT | 2004年 / 09期

关键词：

Sonogashira; palladium; enynes; benzyl halides; alkynes; four-component coupling;

D O I：

10.1055/s-2004-829079

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Unexpected reactivity of benzyl halides with 1-alkynes in Sonogashira reaction promotes in a single-step process the construction of three carbon-carbon bonds regio- and stereoselectively and afforded highly substituted enynes in fair to good yields. The formation of the coupling adduct in this palladium-mediated four-component domino procedure is rationalized by an unprecedented tandem Sonogashira benzylpalladation Sonogashira sequence.

引用

收藏

页码：1503 / 1508

页数：6

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