Amyotrophic lateral sclerosis as a complex genetic disease

被引：76

作者：

Simpson, Claire L. ^{[1
]}

Al-Chalabi, Ammar ^{[1
]}

机构：

[1] Kings Coll London, MRC, Ctr Neurodegenerat Res P043, London SE5 8AF, England

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2006年 / 1762卷 / 11-12期

关键词：

complex disease; complex genetic; amyotrophic lateral sclerosis; sporadic; association study; gene; genetic;

D O I：

10.1016/j.bbadis.2006.08.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In complex diseases like ALS, there are multiple genetic and environmental factors all contributing to disease liability. The genetic factors causing susceptibility to developing ALS can be considered a spectrum from single genes with large effect sizes causing classical Mendelian ALS, to genes of smaller effect, producing apparently sporadic disease. We examine the statistical genetic principles that underpin this model and review what is known about ALS as a disease with complex genetics. (c) 2006 Published by Elsevier B.V.

引用

页码：973 / 985

页数：13

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