Flanking gene and genetic background problems in genetically manipulated mice

被引：97

作者：

Crusio, WE ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Brudnick Neuropsychiat Res Inst, Worcester, MA 01604 USA

来源：

BIOLOGICAL PSYCHIATRY | 2004年 / 56卷 / 06期

关键词：

mutants; linkage; dominance; genetics;

D O I：

10.1016/j.biopsych.2003.12.026

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mice carrying engineered genetic modifications have become an indispensable tool in the study of gene functioning. The interpretation of results obtained with targeted mutants is not completely straight forward, however, because of genetic complications due to linkage and epistasis. Effects of closely linked genes flanking the targeted locus might sometimes be responsible for phenotypic changes ascribed to the null mutation. The effects of the latter might also be modified by the general genetic background. This review presents some examples and discusses some simple strategies to deal with these complications.

引用

页码：381 / 385

页数：5

共 37 条

[1] A behavioral and neuroanatomical assessment of an inbred substrain of 129 mice with behavioral comparisons to C57BL/6J mice [J].

Balogh, SA ;

McDowell, CS ;

Stavnezer, AJ ;

Denenberg, VH .

BRAIN RESEARCH, 1999, 836 (1-2) :38-48

[2] Supersonic congenics? [J].

Behringer, R .

NATURE GENETICS, 1998, 18 (02) :108-108

[3] Mapping of quantitative trait loci with knockout/congenic strains [J].

Bolivar, VJ ;

Cook, MN ;

Flaherty, L .

GENOME RESEARCH, 2001, 11 (09) :1549-1552

[4] Unusual behavioral phenotypes of inbred mouse strains - Commentary [J].

Crawley, JN .

TRENDS IN NEUROSCIENCES, 1996, 19 (05) :181-182

[5] Gene-targeting studies: New methods, old problems - Commentary [J].

Crusio, WE .

TRENDS IN NEUROSCIENCES, 1996, 19 (05) :186-187

[6] 'My mouse has no phenotype' [J].

Crusio, WE .

GENES BRAIN AND BEHAVIOR, 2002, 1 (02) :71-71

[7]

Crusio Wim E., 1999, Trends in Neurosciences, V22, P100, DOI 10.1016/S0166-2236(98)01385-X

[8]

Ehrman L, 1981, BEHAV GENETICS EVOLU

[9] Revised nomenclature for strain 129 mice [J].

Festing, MFW ;

Simpson, EM ;

Davisson, MT ;

Mobraaten, LE .

MAMMALIAN GENOME, 1999, 10 (08) :836-836

[10]

FULLER JL, 1978, FDN BHEAV GENETICS

← 1 2 3 4 →