Mapping of the full length and the truncated interleukin-18 receptor alpha in the mouse brain

被引：40

作者：

Alboni, Silvia ^{[1
]}

Cervia, Davide ^{[2
]}

Ross, Brendon ^{[3
]}

Montanari, Claudia ^{[1
]}

Gonzalez, Alejandro Sanchez ^{[3
]}

Sanchez-Alavez, Manuel ^{[3
]}

Marcondes, Maria Cecilia Garibaldi ^{[3
]}

De Vries, David ^{[3
]}

Sugama, Shuei ^{[4
]}

Brunello, Nicoletta ^{[1
]}

Blom, Joan ^{[5
]}

Tascedda, Fabio ^{[1
]}

Conti, Bruno ^{[3
]}

机构：

[1] Univ Modena & Reggio Emilia, Dept Biomed Sci, I-41100 Modena, Italy

[2] Univ Tuscia, Dept Environm Sci, Viterbo, Italy

[3] Scripps Res Inst, Mol & Integrat Neurosci Dept, Harold L Dorris Neurol Res Ctr, La Jolla, CA USA

[4] Nippon Med Sch, Dept Physiol, Tokyo 113, Japan

[5] Univ Modena & Reggio Emilia, Dept Paediat, I-41100 Modena, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2009年 / 214卷 / 1-2期

关键词：

Interleukin; Receptor; IL-18; IL-18R; Isoform; Brain; LATERAL PREOPTIC AREA; RAT DENTATE GYRUS; MICROGLIAL ACTIVATION; ALZHEIMERS-DISEASE; ACCESSORY PROTEIN; DECOY RECEPTOR; MESSENGER-RNA; IL-18; EXPRESSION; MICE;

D O I：

10.1016/j.jneuroim.2009.06.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The cytokine IL-18 acts on the CNS both in physiological and pathological conditions. Its action occurs through the heterodimeric receptor IL-18R alpha\beta. To better understand IL-18 central effects, we investigated in the mouse brain the distribution of two IL-18R alpha transcripts, a full length and an isoform lacking the intracellular domain hypothesized to be a decoy receptor. Both isoforms were expressed in neurons throughout the brain primarily with overlapping distribution but also with some unique pattern. These data suggest that IL-18 may modulate neuronal functions and that its action may be regulated through expression of a decoy receptor. (c) 2009 Elsevier B.V. All rights reserved.

引用

页码：43 / 54

页数：12

共 52 条

[1] Protective effect of IL-18 on kainate- and IL-1β-Induced cerebellar ataxia in mice [J].

Andoh, Tsugunobu ;

Kishi, Hiroyuki ;

Motoki, Kazumi ;

Nakanishi, Kenji ;

Kuraishi, Yasushi ;

Muraguchi, Atsushi .

JOURNAL OF IMMUNOLOGY, 2008, 180 (04) :2322-2328

[2] Identification of a truncated IL-18β mRNA:: a putative regulator of IL-18 expressed in rat brain [J].

Andre, R ;

Wheeler, RD ;

Collins, PD ;

Luheshi, GN ;

Pickering-Brown, S ;

Kimber, I ;

Rothwell, NJ ;

Pinteaux, E .

JOURNAL OF NEUROIMMUNOLOGY, 2003, 145 (1-2) :40-45

[3] Interleukin 18 gene polymorphisms predict risk and outcome of Alzheimer's disease [J].

Bossu, Paola ;

Ciaramella, Antonio ;

Moro, Maria Luisa ;

Bellincampi, Lorenza ;

Bernardini, Sergio ;

Federici, Giorgio ;

Trequattrini, Alberto ;

Macciardi, Fabio ;

Spoletini, Ilaria ;

Di Iulio, Fulvia ;

Caltagirone, Carlo ;

Spalletta, Gianfranco .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2007, 78 (08) :807-811

[4] IL-1β scavenging by the type IIIL-1 decoy receptor in human neutrophils [J].

Bourke, E ;

Cassetti, A ;

Villa, A ;

Fadlon, E ;

Colotta, F ;

Mantovani, A .

JOURNAL OF IMMUNOLOGY, 2003, 170 (12) :5999-6005

[5] THE TYPE-II DECOY RECEPTOR - A NOVEL REGULATORY PATHWAY FOR INTERLEUKIN-1 [J].

COLOTTA, F ;

DOWER, SK ;

SIMS, JE ;

MANTOVANI, A .

IMMUNOLOGY TODAY, 1994, 15 (12) :562-566

[6] INTERLEUKIN-1 TYPE-II RECEPTOR - A DECOY TARGET FOR IL-1 THAT IS REGULATED BY IL-4 [J].

COLOTTA, F ;

RE, F ;

MUZIO, M ;

BERTINI, R ;

POLENTARUTTI, N ;

SIRONI, M ;

GIRI, JG ;

DOWER, SK ;

SIMS, JE ;

MANTOVANI, A .

SCIENCE, 1993, 261 (5120) :472-475

[7] Cultures of astrocytes and microglia express interleukin 18 [J].

Conti, B ;

Park, LCH ;

Calingasan, NY ;

Kim, Y ;

Kim, H ;

Bae, Y ;

Gibson, GE ;

Joh, TH .

MOLECULAR BRAIN RESEARCH, 1999, 67 (01) :46-52

[8] A role for inflammatory mediators in the IL-18 mediated attenuation of UP in the rat dentate gyrus [J].

Cumiskey, D. ;

Curran, B. P. ;

Herron, C. E. ;

O'Connor, J. J. .

NEUROPHARMACOLOGY, 2007, 52 (08) :1616-1623

[9] Interleukin-18 mediated inhibition of LTP in the rat dentate gyrus is attenuated in the presence of mGluR antagonists [J].

Cumiskey, Derval ;

Pickering, Mark ;

O'Connor, John J. .

NEUROSCIENCE LETTERS, 2007, 412 (03) :206-210

[10] The pro-inflammatory cytokine interleukin-18 impairs long-term potentiation and NMDA receptor-mediated transmission in the rat hippocampus in vitro [J].

Curran, B ;

O'Connor, JJ .

NEUROSCIENCE, 2001, 108 (01) :83-90

← 1 2 3 4 5 6 →