Partition coefficients (free ligands and their iron(III) complexes) and lipophilic behavior of new abiotic chelators. Correlation to biological activity

被引：18

作者：

Thomas, F ^{[1
]}

Baret, P ^{[1
]}

Imbert, D ^{[1
]}

Pierre, JL ^{[1
]}

Serratrice, G ^{[1
]}

机构：

[1] Univ Grenoble 1, CNRS, UMR 5616, LEDSS,Lab Chim Biomimet, F-38041 Grenoble 9, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 20期

关键词：

D O I：

10.1016/S0960-894X(99)00527-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Partition coefficients between n-octanol and water have been measured for ten tripodal ligands with catecholate or hydroxyquinolinate or pyridinophenolate chelating subunits and for their iron(III) complexes. The abilities of the ligands to cross an octanol phase and to extract ferric ion from its EDTA complex in an aqueous phase are studied. Correlation with biological properties are discussed, (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：3035 / 3040

页数：6

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