CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation

被引：314

作者：

Auffray, Cedric ^{[1
]}

Fogg, Darin K. ^{[1
]}

Narni-Mancinelli, Emilie ^{[2
]}

Senechal, Brigitte ^{[1
]}

Trouillet, Celine ^{[1
,3
]}

Saederup, Noah ^{[4
]}

Leemput, Julia ^{[5
]}

Bigot, Karine ^{[5
]}

Campisi, Laura

Abitbol, Marc ^{[5
]}

Molina, Thierry ^{[1
]}

Charo, Israel ^{[4
]}

Hume, David A. ^{[6
,7
]}

Cumano, Ana ^{[8
]}

Lauvau, Gregoire ^{[2
]}

Geissmann, Frederic ^{[1
,3
]}

机构：

[1] Univ Paris 05, INSERM, Lab Biol Mononucl Phagocyte Syst, U838, F-75015 Paris, France

[2] Univ Nice Sophia Antipolis, INSERM, U924, F-06560 Valbonne, France

[3] Kings Coll London, Div Immunity Infect & Inflammatory Dis, Ctr Inflammat Biol, London SE1 9RT, England

[4] Univ Calif San Francisco, Gladstone Inst Cardiovasc Dis, San Francisco, CA 94158 USA

[5] Univ Paris 05, Ctr Etud & Rech Therapeut Ophtalmol, F-75015 Paris, France

[6] Univ Edinburgh, Roslin Inst, Roslin EH25 9PS, Midlothian, Scotland

[7] Univ Edinburgh, Royal Dick Sch Vet Studies, Roslin EH25 9PS, Midlothian, Scotland

[8] INSERM, Unite Dev Lymphocytes, U668, F-75015 Paris, France

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2009年 / 206卷 / 03期

关键词：

FRACTALKINE RECEPTOR CX(3)CR1; STIMULATING FACTOR-1 RECEPTOR; DENDRITIC CELL-DEVELOPMENT; MOUSE BONE-MARROW; BACTERIAL-INFECTION; MICE LACKING; FLT3; LIGAND; CHEMOKINE RECEPTOR; MONOCYTE SUBSETS; IN-VIVO;

D O I：

10.1084/jem.20081385

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

CX(3)CR1 expression is associated with the commitment of CSF-1R(+) myeloid precursors to the macrophage/dendritic cell (DC) lineage. However, the relationship of the CSF-1R(+) CX(3)CR1(+) macrophage/DC precursor (MDP) with other DC precursors and the role of CX(3)CR1 in macrophage and DC development remain unclear. We show that MDPs give rise to conventional DCs (cDCs), plasmacytoid DCs (PDCs), and monocytes, including Gr1(+) inflammatory monocytes that differentiate into TipDCs during infection. CX(3)CR1 deficiency selectively impairs the recruitment of blood Gr1(+) monocytes in the spleen after transfer and during acute Listeria monocytogenes infection but does not affect the development of monocytes, cDCs, and PDCs.

引用

页码：595 / 606

页数：12

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