Diabetes reduces growth and body composition more in male than in female rats

被引:30
作者
Cortright, RN
Collins, HL
Chandler, MP
Lemon, PWR
DiCarlo, SE
机构
[1] NE OHIO UNIV, COLL MED, DEPT PHYSIOL, ROOTSTOWN, OH 44272 USA
[2] KENT STATE UNIV, APPL PHYSIOL LAB, KENT, OH 44242 USA
关键词
diabetes; linear growth; body composition; gender differences;
D O I
10.1016/S0031-9384(96)00222-3
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
Food restriction and/or starvation has a consistently greater and more permanent effect an physical growth in males than in females. Because diabetes may be viewed as being analogous to starvation, we tested the hypothesis that diabetes would reduce growth more in male than in female rats. Diabetes was induced with streptozotocin (65-125 mg/kg IF) at 3 weeks of age in 7 female and IO male Lewis rats. Body weight (BW) and brood glucose (bGlc) were measured over the following 8 weeks. Subsequently, animals were assessed for body (ano-nasal; ANL) and bone length (tibia; TBL) and chemically analyzed for body composition. Results were compared to age-matched controls (male = ii female = 9). A 2-way factorial analysis of covariance (ANCOVA), with body weight as the covariate, was used to test for statistical significance for the effects of gender and diabetes on body composition (fat and protein mass) and linear growth because control males and females had significantly different body weights. There were no significant differences in bGlc between genders. However, males had a greater decrease from controls in BW (-45% vs. -13%), protein (-48% vs. -11%), fat (-89% vs. -65%), TBL (-13% vs. 0%), and ANL (-17% vs. -5%) compared to females. In addition, males had a greater absolute decrease from controls in protein (-40 g vs. -5 g) and fat (-39 g vs. -23 g) mass. These results suggest that male rats are more susceptible than females to the deleterious effects of diabetes on linear growth and body composition. Copyright (C) 1996 Elsevier Science Inc.
引用
收藏
页码:1233 / 1238
页数:6
相关论文
共 27 条
[1]  
CORTRIGHT RN, 1994, FASEB J, V8, pA945
[2]   EFFECTS OF EXERCISE TRAINING ON ENERGY-BALANCE OF OVARIECTOMIZED RATS [J].
DENIS, R ;
ROCHON, L ;
DESHAIES, Y .
AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 253 (05) :R740-R745
[3]   ESTRADIOL AND INSULIN - INDEPENDENT EFFECTS ON EATING AND BODY-WEIGHT IN RATS [J].
DUDLEY, SD ;
GENTRY, RT ;
SILVERMAN, BS ;
WADE, GN .
PHYSIOLOGY & BEHAVIOR, 1979, 22 (01) :63-67
[4]   SEX-DIFFERENCES IN ENERGY-INTAKE AND EXPENDITURE [J].
DURNIN, JVGA .
PROCEEDINGS OF THE NUTRITION SOCIETY, 1976, 35 (02) :145-154
[5]  
FEREMBACH D, 1978, RECHERCHE, V9, P14
[6]   HYPERPHAGIA IN RATS WITH EXPERIMENTAL DIABETES-MELLITUS - RESPONSE TO A DECREASED SUPPLY OF UTILIZABLE FUELS [J].
FRIEDMAN, MI .
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1978, 92 (01) :109-117
[7]   EFFECT OF PROGESTERONE ON QUANTITY + DISTRIBUTION OF BODY FAT IN FEMALE RAT [J].
GALLETTI, F ;
KLOPPER, A .
ACTA ENDOCRINOLOGICA, 1964, 46 (03) :379-&
[8]   FAT WEIGHT AND FAT PLACEMENT IN THE FEMALE [J].
GARN, SM .
SCIENCE, 1957, 125 (3257) :1091-1092
[9]   ESTROGEN-INDUCED EFFECTS ON FOOD-INTAKE AND BODY-WEIGHT IN OVARIECTOMIZED, PARTIALLY LIPECTOMIZED RATS [J].
GAVIN, ML ;
GRAY, JM ;
JOHNSON, PR .
PHYSIOLOGY & BEHAVIOR, 1984, 32 (01) :55-59
[10]   EFFECTS OF OVARIAN-STEROIDS ON ENERGY-BALANCE IN RATS FED A HIGHLY PALATABLE DIET [J].
GUYARD, B ;
FRICKER, J ;
BRIGANT, L ;
BETOULLE, D ;
APFELBAUM, M .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1991, 40 (05) :529-533