A tick-borne segmented RNA virus contains genome segments derived from unsegmented viral ancestors

被引：170

作者：

Qin, Xin-Cheng ^{[1
]}

Shi, Mang ^{[1
,2
,3
]}

Tian, Jun-Hua ^{[4
]}

Lin, Xian-Dan ^{[5
]}

Gao, Dong-Ya ^{[1
]}

He, Jin-Rong ^{[1
]}

Wang, Jian-Bo ^{[1
]}

Li, Ci-Xiu ^{[1
]}

Kang, Yan-Jun ^{[1
]}

Yu, Bin ^{[4
]}

Zhou, Dun-Jin ^{[4
]}

Xu, Jianguo ^{[1
]}

Plyusnin, Alexander ^{[1
,6
]}

Holmes, Edward C. ^{[1
,2
,3
]}

Zhang, Yong-Zhen ^{[1
]}

机构：

[1] Chinese Ctr Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Collaborat Innovat Ctr Diag & Treatment Infect Di, Dept Zoonoses,Natl Inst Communicable Dis Control, Beijing 100206, Peoples R China

[2] Univ Sydney, Marie Bashir Inst Infect Dis & Biosecur, Charles Perkins Ctr, Sch Biol Sci, Sydney, NSW 2006, Australia

[3] Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia

[4] Wuhan Ctr Dis Control & Prevent, Wuhan 430015, Peoples R China

[5] Wenzhou Ctr Dis Control & Prevent, Wenzhou 325001, Peoples R China

[6] Univ Helsinki, Dept Virol, Haartman Inst, Helsinki 00014, Finland

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2014年 / 111卷 / 18期

基金：

中国国家自然科学基金; 英国医学研究理事会;

关键词：

evolution; segmentation; ENCEPHALITIS-VIRUS; TOXOCARA-CANIS; FLAVIVIRUS; IDENTIFICATION; TRANSMISSION; PHYLOGENY; PROTEINS; GENES; CHINA;

D O I：

10.1073/pnas.1324194111

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Although segmented and unsegmented RNA viruses are commonplace, the evolutionary links between these two very different forms of genome organization are unclear. We report the discovery and characterization of a tick-borne virus-Jingmen tick virus (JMTV)-that reveals an unexpected connection between segmented and unsegmented RNA viruses. The JMTV genome comprises four segments, two of which are related to the nonstructural protein genes of the genus Flavivirus (family Flaviviridae), whereas the remaining segments are unique to this virus, have no known homologs, and contain a number of features indicative of structural protein genes. Remarkably, homology searching revealed that sequences related to JMTV were present in the cDNA library from Toxocara canis (dog roundworm; Nematoda), and that shared strong sequence and structural resemblances. Epidemiological studies showed that JMTV is distributed in tick populations across China, especially Rhipicephalus and Haemaphysalis spp., and experiences frequent host-switching and genomic reassortment. To our knowledge, JMTV is the first example of a segmented RNA virus with a genome derived in part from unsegmented viral ancestors.

引用

页码：6744 / 6749

页数：6

共 30 条

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