Signaling components involved in Bcl-w-induced migration of gastric cancer cells

被引：28

作者：

Bae, In Hwa ^{[1
]}

Yoon, Sung Hwan ^{[1
]}

Lee, Seung Bum ^{[1
]}

Park, Jong Kuk ^{[1
]}

Ho, Jin-Nyoung ^{[1
]}

Um, Hong-Duck ^{[1
]}

机构：

[1] Korea Inst Radiol & Med Sci, Lab Radiat Canc Biol, Seoul 139706, South Korea

来源：

CANCER LETTERS | 2009年 / 277卷 / 01期

关键词：

Bcl-w; Migration; Cell signaling; Gastric carcinoma; FOCAL ADHESION KINASE; PLASMINOGEN-ACTIVATOR RECEPTOR; EXPRESSION; FAMILY; SUPPRESSES; PROTEINS; BLOCKING; CLONING; DEATH; ACID;

D O I：

10.1016/j.canlet.2008.11.022

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

We have previously reported that Bcl-w enhances the invasiveness of gastric cancer cells by inducing MMP-2 expression via phosphoinositide 3-kinase (PI3K), Akt and Sp1. This study demonstrates that Bcl-w additionally induces uPA expression and FAK activation. Analyses of the hierarchical relationship and functions of these components showed that the PI3K-Akt-Sp1 pathway also mediates the induction of uPA, and that both uPA and MMP-2 contribute to Bcl-w-induced invasion via the stimulation of the FAK-dependent migratory pathway. These findings significantly advance our understandings of the Bcl-w-induced signaling processes that results in the migration and invasion of cancer cells. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：22 / 28

页数：7

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