Significant (re)location: how to use chromatin and/or abundant proteins as messages of life and death

被引：46

作者：

Bianchi, ME ^{[1
]}

机构：

[1] San Raffaele Univ, I-20132 Milan, Italy

来源：

TRENDS IN CELL BIOLOGY | 2004年 / 14卷 / 06期

关键词：

D O I：

10.1016/j.tcb.2004.04.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Chromatin proteins package the genome and modulate its accessibility for transcription and all other transactions. However, recent work reveals that the chromatin proteins histone H1 and high-mobility group box protein 1 can also be used as signals during cell apoptosis and necrosis, respectively. Is there a reason why dying cells should use their own chromatin to signal that they are going to die or how they have died? This article will argue that any protein in a segregated compartment can be useful for signalling purposes when it leaves its usual location. Might actins, tubulins, lamins and DNA itself have signalling roles?

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页码：287 / 293

页数：7

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