The role of free radical reactions with haemoglobin and thalassaemia

被引：11

作者：

Anastassopoulou, J ^{[1
]}

Anifantakis, B ^{[1
]}

Anifantakis, ZA ^{[1
]}

Dovas, A ^{[1
]}

Theophanides, T ^{[1
]}

机构：

[1] Natl Tech Univ Athens, Dept Chem Engn, Athens 15780, Greece

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2000年 / 79卷 / 1-4期

关键词：

thalassaemia; ATP-Fe3+; AMP-Fe3+; free radicals; haemoglobin;

D O I：

10.1016/S0162-0134(99)00247-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is well known that all living systems depend on iron to transport (haemoglobin), store (myoglobin) and utilize (cytochromes, cytochrome oxide) oxygen for respiration. Iron is an essential component in the active sites of the enzyme that protects against oxidation, such as the iron superoxide dismutase, in bacteria and plants. In normal human plasma almost all iron loading of transferrin is 20-30% maximum. In this presentation we review and summarize recent developments in our understanding of iron transport and storage in living systems. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：327 / 329

页数：3

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