Bone morphogenetic protein receptors and signal transduction

被引：836

作者：

Miyazono, Kohei ^{[1
]}

Kamiya, Yuto ^{[1
]}

Morikawa, Masato ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Mol Pathol, Tokyo 1130033, Japan

来源：

JOURNAL OF BIOCHEMISTRY | 2010年 / 147卷 / 01期

基金：

日本学术振兴会;

关键词：

BMP; GDF; serine-threonine kinase; Smad; TGF-beta; GROWTH-FACTOR-BETA; GUIDANCE MOLECULE RGMA; TUMOR-SUPPRESSOR GENE; II RECEPTOR; CRYSTAL-STRUCTURE; BMP RECEPTOR; TRANSCRIPTIONAL REGULATION; TRANSFORMING GROWTH-FACTOR-BETA-1; SMAD1/5; PHOSPHORYLATION; PULMONARY-HYPERTENSION;

D O I：

10.1093/jb/mvp148

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bone morphogenetic proteins (BMPs) exhibit broad spectra of biological activities in various tissues, including bone, cartilage, blood vessels, heart, kidney, neurons, liver and lung. BMPs are members of the transforming growth factor-beta (TGF-beta) family that bind to type II and type I serine-threonine kinase receptors, and transduce signals through Smad and non-Smad signalling pathways. Recent findings have revealed that BMP signalling is finely tuned by various mechanisms in both positive and negative fashions. Perturbations of BMP signalling pathways are linked to a wide variety of clinical disorders, including vascular diseases, skeletal diseases and cancer. Administration of recombinant BMP ligands and increasing endogenous expression of BMPs provide therapeutic effects on some diseases. The recent development of BMP receptor inhibitors may also prove useful for some clinical diseases induced by hyperactivation of the BMP signalling pathways.

引用

页码：35 / 51

页数：17

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