Glycosylation and prion protein

被引：68

作者：

Rudd, PM ^{[1
]}

Merry, AH ^{[1
]}

Wormald, MR ^{[1
]}

Dwek, RA ^{[1
]}

机构：

[1] Univ Oxford, Oxford Glycobiol Inst, Oxford OX1 3QU, England

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2002年 / 12卷 / 05期

关键词：

D O I：

10.1016/S0959-440X(02)00377-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent advances have elucidated the detailed glycosylation of the prion protein and highlighted the size of the sugars, which shield large areas of the protein and confer some conformational stability on the normal cellular form. The reliability of SDS-PAGE banding patterns of different 'glycoforms' as a diagnostics tool has been discussed. The possibility exists that the glycans may play a role in the location of the prion protein on the neuronal cell surface. Alternative topologies and tethering of the prion glycoprotein on the cell membrane affect glycan site occupancy and may play a role in disease pathogenesis.

引用

页码：578 / 586

页数：9

共 64 条

[1] Prion rods contain an inert polysaccharide scaffold [J].

Appel, TR ;

Dumpitak, C ;

Matthiesen, U ;

Riesner, D .

BIOLOGICAL CHEMISTRY, 1999, 380 (11) :1295-1306

[2] Nervous and nonnervous cell transduction by recombinant adenoviruses that inducibly express the human PrP [J].

Arrabal, S ;

Touchard, M ;

Mouthon, F ;

Klonjkowski, B ;

Deslys, JP ;

Dormont, D ;

Eloit, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 285 (03) :623-632

[3] Opposite effects of dextran sulfate 500, the polyene antibiotic MS-8209, and Congo red on accumulation of the protease-resistant isoform of PrP in the spleens of mice inoculated intraperitoneally with the scrapie agent [J].

Beringue, V ;

Adjou, KT ;

Lamoury, F ;

Maignien, T ;

Deslys, JP ;

Race, R ;

Dormont, D .

JOURNAL OF VIROLOGY, 2000, 74 (12) :5432-5440

[4] Prion protein glycosylation is sensitive to redox change [J].

Capellari, S ;

Zaidi, SIA ;

Urig, CB ;

Perry, G ;

Smith, MA ;

Petersen, RB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (49) :34846-34850

[5] Effect of the E200K mutation on prion protein metabolism - Comparative study of a cell model and human brain [J].

Capellari, S ;

Parchi, P ;

Russo, CM ;

Sanford, J ;

Sy, MS ;

Gambetti, P ;

Petersen, RB .

AMERICAN JOURNAL OF PATHOLOGY, 2000, 157 (02) :613-622

[6] Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD [J].

Collinge, J ;

Sidle, KCL ;

Meads, J ;

Ironside, J ;

Hill, AF .

NATURE, 1996, 383 (6602) :685-690

[7] PrPC glycoform heterogeneity as a function of brain region: Implications for selective targeting of neurons by prion strains [J].

DeArmond, SJ ;

Qiu, Y ;

Sanchez, H ;

Spilman, PR ;

Ninchak-Casey, A ;

Alonso, D ;

Daggett, V .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1999, 58 (09) :1000-1009

[8] Selective neuronal targeting in prion disease [J].

DeArmond, SJ ;

Sánchez, H ;

Yehiely, F ;

Qiu, Y ;

Ninchak-Casey, A ;

Daggett, V ;

Camerino, AP ;

Cayetano, J ;

Rogers, M ;

Groth, D ;

Torchia, M ;

Tremblay, P ;

Scott, MR ;

Cohen, FE ;

Prusiner, SB .

NEURON, 1997, 19 (06) :1337-1348

[9] Chaperone-supervised conversion of prion protein to its protease-resistant form [J].

DebBurman, SK ;

Raymond, GJ ;

Caughey, B ;

Lindquist, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (25) :13938-13943

[10] The glycan processing and site occupancy of recombinant Thy-1 is markedly affected by the presence of a glycosylphosphatidylinositol anchor [J].

Devasahayam, M ;

Catalino, PD ;

Rudd, PM ;

Dwek, RA ;

Barclay, AN .

GLYCOBIOLOGY, 1999, 9 (12) :1381-1387

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