Stage- and cell-specific expression of Dnmt3a and Dnmt3b during embryogenesis

被引：164

作者：

Watanabe, D

Suetake, I

Tada, T

Tajima, S

机构：

[1] Osaka Univ, Inst Prot Res, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Inst Mol & Cellular Biol, Suita, Osaka 565, Japan

[3] Kyoto Univ, Inst Frontier Med Sci, Sakyo Ku, Kyoto 6068507, Japan

来源：

MECHANISMS OF DEVELOPMENT | 2002年 / 118卷 / 1-2期

关键词：

mouse embryogenesis; DNA methylation pattern; Dnmt3a; Dnmt3b; de novo-type DNA methyltransferase;

D O I：

10.1016/S0925-4773(02)00242-3

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

DNA methylation is essential for development. Two DNA methyltransferases, Dnmt3a and Dnmt3b, contribute to the creation of DNA methylation patterns in embryos. We demonstrated that the Dnmt3a and Dnmt3b proteins are expressed at different stages of embryogenesis. Dnmt3b is specifically expressed in totipotent embryonic cells, such as inner cell mass, epiblast and embryonic ectoderm cells, whilst Dnmt3a is significantly and ubiquitously expressed after E10.5. The difference in the expression stages of the Dnmt3a and Dnmt3b proteins may contribute to their distinct functions during the embryogenesis. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

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页码：187 / 190

页数：4

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