To Nibble at Plant Resistance Proteins

被引：131

作者：

Takken, F. L. W. ^{[1
]}

Tameling, W. I. L. ^{[2
]}

机构：

[1] Univ Amsterdam, SILS, NL-1090 GE Amsterdam, Netherlands

[2] Wageningen Univ, Phytopathol Lab, NL-6700 EE Wageningen, Netherlands

来源：

SCIENCE | 2009年 / 324卷 / 5928期

关键词：

NB-LRR PROTEIN; NUCLEOTIDE-BINDING; CASPASE-1; ACTIVATION; ATP HYDROLYSIS; APOPTOSOME; RECOGNITION; PERCEPTION; MUTATIONS; EXCHANGE; DOMAINS;

D O I：

10.1126/science.1171666

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To intercept invading microbes that threaten growth and reproduction, plants evolved a sophisticated innate immune system. Recognition of specialized pathogens is mediated by resistance proteins that function as molecular switches. Pathogen perception by these multidomain proteins seems to trigger a series of conformational changes dependent on nucleotide exchange. The activated resistance protein switches on host defenses, often culminating in the death of infected cells. Given their control over life and death, activity of these proteins requires tight regulation that involves intramolecular interactions between the various domains.

引用

页码：744 / 746

页数：3

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