Neurophysiological evidence of error-monitoring deficits in patients with schizophrenia

被引：162

作者：

Alain, C

McNeely, HE

He, Y

Christensen, BK

West, R

机构：

[1] Baycrest Ctr Geriatr Care, Rotman Res Inst, Toronto, ON M6A 2E1, Canada

[2] Ctr Addict & Mental Hlth, Toronto, ON, Canada

[3] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[4] Univ Notre Dame, Notre Dame, IN 46556 USA

[5] Univ Toronto, Dept Psychol, Toronto, ON M5S 1A1, Canada

来源：

CEREBRAL CORTEX | 2002年 / 12卷 / 08期

关键词：

D O I：

10.1093/cercor/12.8.840

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study was designed to investigate the time-course of neural activity underlying the disruption of response monitoring in patients with schizophrenia. Event-related brain potentials were recorded from 12 patients with schizophrenia and from 12 age-matched controls while they performed a computerized version of the Stroop color-naming task. In control participants, but not in patients with schizophrenia, intrusion errors elicited an error-related negativity (ERN) that peaked at similar to40 ms after the response and was maximum over the central region of the scalp. Brain electrical source analysis revealed an anterior cingulate generator for the ERN. Patients also showed reduced error-related slowing of response time following intrusion errors. These findings provide neuro-physiological evidence indicating that deficits in error monitoring in schizophrenia arise from a disruption of error-detection processes, possibly attributable to anterior cingulate dysfunction.

引用

页码：840 / 846

页数：7

共 32 条

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