A chiral sensor for arginine and lysine

被引：58

作者：

Wehner, M

Schrader, T

Finocchiaro, P

Failla, S

Consiglio, G

机构：

[1] Univ Dusseldorf, Inst Organ Chem & Makromol Chem, D-40225 Dusseldorf, Germany

[2] Univ Catania, Fac Ingn, Ist Chim, I-95125 Catania, Italy

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 05期

关键词：

D O I：

10.1021/ol991355u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] We provide access to a new class of C-1- or C-2-symmetrical host molecules 1 and 2 based on a spirobisindane skeleton, Whereas 1 is selective for short, rigid diamines, 2 prefers longer alpha,omega-dications. Of all the amino acid methyl esters, only those of lysine and arginine with the correct distance between their cationic groups form strong 1:1 complexes in DMSO with 2, NMR titrations reveal high association constants as well as discrimination between the enantiomers of lysine and arginine.

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页码：605 / 608

页数：4

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