Regional variation in CCR5-Δ32 gene distribution among women from the USHIV Epidemiology Research Study (HERS)

被引：10

作者：

Downer, MV

Hodge, T

Smith, DK

Qari, SH

Schuman, P

Mayer, KH

Klein, RS

Vlahov, D

Gardner, LI

McNicholl, JM

机构：

[1] Ctr Dis Control & Prevent, Div AIDS STD & TB Lab Res, Natl Ctr Infect Dis, Immunogenet Lab, Atlanta, GA 30333 USA

[2] Ctr Dis Control & Prevent, Div HIV AIDS Prevent Surveillance & Epidemiol, Natl Ctr HIV STD & TB Prevent, Atlanta, GA 30333 USA

[3] Wayne State Univ, Sch Med, Div Infect Dis, Detroit, MI USA

[4] Brown Univ, Div Infect Dis, Dept Med, Providence, RI 02912 USA

[5] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Med, Bronx, NY 10467 USA

[6] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Epidemiol & Social Med, Bronx, NY 10467 USA

[7] Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Epidemiol, Baltimore, MD USA

来源：

GENES AND IMMUNITY | 2002年 / 3卷 / 05期

关键词：

chemokine receptor; regional difference; black/African American; HIV-1; infection;

D O I：

10.1038/sj.gene.6363884

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The CCR5-Delta32 genotype is known to influence HIV-1 transmission and disease. We genotyped 1301 US women of various races/ethnicities participating in the HIV Epidemiologic Research Study. None was homozygous for CCR5Delta32. The distribution of heterozygotes was similar in HIV-1 infected and uninfected women. Thirty-seven (11.8%) white, 28 (3.7%) blacks/African Americans (AA), seven (3.3%) Hispanics/Latinas, and one (6.6%) other race/ethnicity were heterozygous. The frequency of heterozygotes differed among sites for all races combined (P = 0.001). More heterozygotes were found in AA women in Rhode Island (8.9%) than in the other sites (3.1%) (P = 0.02), while heterozygosity in white women was most common in Maryland (28.6%) (P = 0.025). These regional differences could be accounted for by racial admixture in AAs, but not in whites. Regional variations should be considered when studying host genetic factors and HIV-1 in US populations.

引用

页码：295 / 298

页数：4

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