Striatal dopamine D2 binding is related to frontal BOLD response during updating of long-term memory representations

被引：33

作者：

Nyberg, Lars ^{[1
,2
,3
]}

Andersson, Micael ^{[2
,3
]}

Forsgren, Lars ^{[4
]}

Jakobsson-Mo, Susanna ^{[1
]}

Larsson, Anne ^{[1
]}

Marklund, Petter ^{[5
,6
]}

Nilsson, Lars-Goran ^{[5
,6
]}

Riklund, Katrine ^{[1
,3
]}

Backman, Lars ^{[7
]}

机构：

[1] Umea Univ, Dept Radiat Sci, S-90187 Umea, Sweden

[2] Umea Univ, Dept Integrat Med Biol, S-90187 Umea, Sweden

[3] Umea Ctr Funct Brain Imaging, Umea, Sweden

[4] Umea Univ, Dept Pharmacol & Clin Neurosci, S-90187 Umea, Sweden

[5] Stockholm Univ, Dept Psychol, Stockholm, Sweden

[6] Stockholm Brain Inst, Stockholm, Sweden

[7] Karolinska Inst, Aging Res Ctr, Stockholm, Sweden

来源：

NEUROIMAGE | 2009年 / 46卷 / 04期

基金：

瑞典研究理事会;

关键词：

POSITRON-EMISSION-TOMOGRAPHY; PREFRONTAL CORTEX; MONTE-CARLO; PROSPECTIVE COHORT; WORKING-MEMORY; BASAL GANGLIA; MODULATION; SIMULATION; RELEASE; SCHIZOPHRENIA;

D O I：

10.1016/j.neuroimage.2009.03.035

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Multi-modal brain imaging was used to examine the relation between individual differences in resting-state striatal dopamine D2 binding and the magnitude of prefrontal BOLD activation during updating of long-term memory (LTM) representations. Increased activity in the left prefrontal cortex was observed when LTM updating was required, and there was a positive correlation between striatal D2 activity and the magnitude of left prefrontal activity during updating. These findings support predictions from neurocomputational models of a relation of dopaminergic neurotransmission to transient cognitive operations and related brain activity. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：1194 / 1199

页数：6

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