The viral protein Apoptin associates with the anaphase-promoting complex to induce G2/M arrest and apoptosis in the absence of p53

被引：108

作者：

Teodoro, JG ^{[1
]}

Heilman, DW ^{[1
]}

Parker, AE ^{[1
]}

Green, MR ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Programs Gene Funct & Express & Mol Med, Worcester, MA 01605 USA

来源：

GENES & DEVELOPMENT | 2004年 / 18卷 / 16期

关键词：

apoptin; apoptosis; G2/M arrest; anaphase-promoting complex/cyclosome; p53-independent; RNA interference;

D O I：

10.1101/gad.1198404

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The chicken anemia virus protein Apoptin induces apoptosis in the absence of p53 by a mechanism that remains to be elucidated. Here we show that in transformed cells, Apoptin is associated with APC1, a subunit of the anaphase-promoting complex/cyclosome (APC/ C). We demonstrate that Apoptin expression, or depletion of APC1 by RNA interference, inhibits APC/C function in p53 null cells, resulting in G2/M arrest and apoptosis. Our results explain the ability of Apoptin to induce apoptosis in the absence of p53 and suggest that the APC/C is an attractive target for anticancer drug development.

引用

页码：1952 / 1957

页数：6

共 24 条

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