A convenient synthetic route to oligonucleotide conjugates

被引：19

作者：

Harrison, JG ^{[1
]}

Balasubramanian, S ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,DEPT CHEM,CAMBRIDGE CB2 1EW,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 08期

关键词：

ANTISENSE OLIGONUCLEOTIDES; ASSOCIATION; LIPOSOMES; AGENTS; DNA;

D O I：

10.1016/S0960-894X(97)00152-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of oligodeoxyribonucleotide 13mers conjugated to cholic, folic, Lipoic and pantothenic acids through thioether and disulphide bonds is described employing a convenient methodology which involves initial preparation of cysteinyl derivatives of the acids on solid phase. (C) 1997 Elsevier Science Ltd.

引用

页码：1041 / 1046

页数：6

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