Background. The French healthcare system offers the possibility of increasing the use of peritoneal. dialysis (PD) by involving in patient care nurses who work in the private system. Objective: This study was conducted to evaluate the impact of a private home-nurse network on one dialysis program. Methods: This was a retrospective study of 239 dialysis patients who started dialysis in our center between 1 January 1998 and 31 December 2003. Results: Of these 239 patients, 142 were treated with hemodialysis and 97 with PD during the study period. Among the PD patients, 3 6 of 97 were treated with assisted PD and 61 of 97 with self-care PD. Assisted-PD patients were older (74 10 vs 52 18 years, p < 0.001) and presented more comorbidity (Chartson Comorbidity Index 7 +/- 2.5 vs 4.3 +/- 2.4, p < 0.05) compared with self-care patients. Continuous ambulatory PD was the modality of choice in the assisted group (32/36). Assisted patients were frequently hospitalized (31/36); actuarial survival free of hospitalization at 6 months was 46%. Patients with nurse assistance had a high risk of peritonitis (actuarial survival free of peritonitis: 52% at 1 year). Technique survival was 85% at 6 months and 58% at 1 year. Actuarial patient survival was 90% at 6 months and 83% at 1 year. Conclusion: Assisted PD enables increased use of PD in incident dialysis patients. However, in view of the comorbidities of the assisted-PD patients, the need for frequent hospitalization has to be taken into account in such a program.