Circular RNA expression profile of knee condyle in osteoarthritis by illumina HiSeq platform

被引：45

作者：

Xiao, Ke ^{[1
]}

Xia, Zenan ^{[1
]}

Feng, Bin ^{[1
]}

Bian, Yanyan ^{[1
]}

Fan, Yu ^{[1
]}

Li, Zeng ^{[1
]}

Wu, Zhihong ^{[2
]}

Qiu, Guixing ^{[1
]}

Weng, Xisheng ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Orthopaed Surg, Beijing, Peoples R China

[2] Peking Union Med Hosp, Cent Lab, Beijing, Peoples R China

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2019年 / 120卷 / 10期

基金：

中国国家自然科学基金;

关键词：

ceRNA network; circRNAs; condyle; gene regulation; osteoarthritis; DEGRADATION; KEGG;

D O I：

10.1002/jcb.29014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Osteoarthritis (OA) is the utmost commonly arising joint disease. Knee condyles play an essential role during OA progression. Circular RNA (or circRNA) is a novel kind of RNA, which, unlike the well-known linear RNA, plays an important regulatory role in OA on the basis of a previous research. In our study, expression of circRNAs in OA knee condyle was measured by illumine sequencing platform. A total of 197 differentially expressed circRNAs, such as hg38_circ_0007474 and hg38_circ_0000118 were identified, and 21 target miRNAs, 2466 source genes and 166 394 circRNA-miRNA-mRNA pairs were predicted. Further analysis was applied on three OA-related circRNAs (hsa_circ_0045714, hsa_circ_0002485, and hsa_circ_0005567). The results were partly verified by previous studies. Further biological research is needed to unfold the possible pathway and therapeutic target of OA.

引用

页码：17500 / 17511

页数：12

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