Effect of acetyl-L-carnitine on hyperactivity and spatial memory deficits of rats exposed to neonatal anoxia

被引：21

作者：

DellAnna, E

Iuvone, L

Calzolari, S

Geloso, MC

机构：

[1] CATHOLIC UNIV,NEUROL INST,ROME,ITALY

[2] CHILD NEUROPSYCHIAT UNIT,TRENT,ITALY

[3] CATHOLIC UNIV,INST HISTOL & EMBRYOL,ROME,ITALY

来源：

NEUROSCIENCE LETTERS | 1997年 / 223卷 / 03期

关键词：

perinatal asphyxia; attention deficit hyperactivity disorder; acetyl-carnitine; hyperactivity; spatial memory; neuroprotection;

D O I：

10.1016/S0304-3940(97)13411-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of acetyl-L-carnitine (ALC) on behavioral deficits following neonatal anoxia (N-2 100% for 25 min at 30 h after birth) was studied in the rat. Transient hyperactivity at P20-P45 postnatal days and permanent spatial memory deficits were shown by anoxic rats. A chronic ALC treatment (50 mg/kg per die injected intraperitoneally from P2, after anoxia, to P60) significantly reduced the transient increase in sniffing, rearing and locomotory activity of anoxic rats, but, mostly, ameliorated the spatial memory performances in a maze at P30-P40 and in a water maze at P50-P60. No behavioral changes were seen in ALC-treated animals that received sham-exposure at birth. On the basis of these results, the use of ALC for the treatment of perinatal asphyctic insults in children is suggested. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：201 / 205

页数：5

共 25 条

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