Risk of non-medullary thyroid cancer influenced by polymorphic variation in the thyroglobulin gene

被引：25

作者：

Matakidou, A

Hamel, N

Popat, S

Henderson, K

Kantemiroff, T

Harmer, C

Clarke, SEM

Houlston, RS ^{[1
]}

Foulkes, WD

机构：

[1] Inst Canc Res, Sect Canc Genet, Sutton SM2 5NG, Surrey, England

[2] Royal Marsden Hosp NHS Trust, Dept Med, Sutton SM2 5TT, Surrey, England

[3] McGill Univ, Sir Mortimer B Davis Jewish Gen Hosp, Canc Prevent Ctr, Montreal, PQ H3T 1E2, Canada

[4] McGill Univ, Montreal Gen Hosp, Res Inst, Dept Med,Div Med Genet, Montreal, PQ H3G 1A2, Canada

[5] Royal Marsden Hosp NHS Trust, Dept Clin Oncol, Sutton SM2 TBG, Surrey, England

[6] Guys & St Thomas Hosp, Dept Nucl Med, London SE1 9RT, England

[7] McGill Univ, Dept Oncol, Program Canc Genet, Montreal, PQ H2W 1S6, Canada

[8] McGill Univ, Dept Human Genet, Program Canc Genet, Montreal, PQ H2W 1S6, Canada

来源：

CARCINOGENESIS | 2004年 / 25卷 / 03期

关键词：

D O I：

10.1093/carcin/bgh027

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Benign thyroid disorders are strong risk factors for non-medullary thyroid cancer (NMTC). Germline variation in Tg (thyroglobulin) and TSHR (thyroid stimulating hormone receptor) confers an increased risk of benign thyroid disorders. To explore the hypothesis that polymorphic variation in these genes affects the risk of NMTC we compared the frequency of TgQ2511R, TSHR-P52T and TSHR-D727E genotypes in two series of NMTC cases and controls (group 1, Canadian 102 cases and 102 controls; group 2, British 202 cases and 298 controls). No significant association was seen with TSHR-P52T and TSHR-D727E genotypes and risk of NMTC. However, the frequency of the R-allele of TgQ2511R was over represented in NMTC cases in both study populations. The odds ratios associated with hetero- and homozygosity for the R-allele were 1.6 (95% confidence interval, 1.1-2.5) and 2.0 (95% confidence interval, 1.2-3.3), respectively. Although the risk of NMTC associated with the TgQ2511R R-allele is modest, its high prevalence in the general population suggests it may make a significant contribution to the incidence of NMTC.

引用

页码：369 / 373

页数：5

共 37 条

[1] Lack of association between polymorphism of the thyrotropin receptor gene and Graves' disease in United Kingdom and Hong Kong Chinese patients: Case control and family-based studies [J].