Kumada-Corriu reactions of alkyl halides with alkynyl nucleophiles

被引：72

作者：

Yang, LM ^{[1
]}

Huang, LF

Luh, TY

机构：

[1] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan

[2] Natl Taiwan Univ, Inst Polymer Sci & Engn, Taipei 106, Taiwan

[3] Acad Sinica, Inst Chem, Taipei 115, Taiwan

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 09期

关键词：

D O I：

10.1021/ol049686g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pd-2(dba)(3)-Ph3P-catalyzed Kumada-Corriu coupling reactions of unactivated alkyl bromides or iodides with an alkynyl nucleophile furnish C-sp-C(sp)3 bond formation, Alkynyl nucleophiles can be alkynyllithiums or the corresponding Grignard reagents. The superior performance of Ph3P ligand over the trialkylphosphine ligands indicates that this cross-coupling reaction may be a reductive-elimination-controlled process.

引用

页码：1461 / 1463

页数：3

共 40 条

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