Small peptidic aldehyde inhibitors of human rhinovirus 3C protease

被引：42

作者：

Shepherd, TA

Cox, GA

McKinney, E

Tang, J

Wakulchik, M

Zimmerman, RE

Villarreal, EC

机构：

[1] Lilly Research Laboratories, Eli Lilly and Company, Indianapolis

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 23期

关键词：

D O I：

10.1016/S0960-894X(96)00537-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Small peptide aldehydes were designed to mimic the preferred substrate requirements for the human rhinovirus 3C protease. Di- and tripeptide aldehydes containing a methionine sulfone as a P-1 surrogate for glutamine show low micromolar enzyme inhibitory and antiviral tissue culture activity. LY338387, obtained in a short and efficient synthesis, appears to validate the protease as a therapeutic target. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2893 / 2896

页数：4

共 17 条

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