Inhibitory and activating receptors involved in immune surveillance by human NK and myeloid cells

被引：58

作者：

Colonna, M ^{[1
]}

Nakajima, H ^{[1
]}

Cella, M ^{[1
]}

机构：

[1] Basel Inst Immunol, CH-4005 Basel, Switzerland

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 1999年 / 66卷 / 05期

关键词：

cell surface molecules; immunoglobulin superfamily; major histocompatibility complex monocytes/macrophages; dendritic cells; basophils; CD48;

D O I：

10.1002/jlb.66.5.718

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We review the structure, cellular distribution, Ligand specificity, and function of two emerging types of receptors involved in natural killer (NK) and myeloid cell recognition of other cells: ILT/LIR/MIR and 2B4 receptors, ILT/LIR/MIR receptors are differentially expressed on lymphoid and myeloid cells and two of them, ILT2 and ILT4, recognize HLA class I molecules, Whereas some receptors inhibit, others induce cell activation. 2B4 is broadly expressed on leukocytes, binds CD48, and mediates non-MHC-restricted cytotoxicity by NK cells.

引用

页码：718 / 722

页数：5

共 33 条

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