Unexpected correlation in the sensitivity of 19 herpes simplex virus strains to types I and II interferons

被引：8

作者：

Arao, Y ^{[1
]}

Ando, Y ^{[1
]}

Narita, M ^{[1
]}

Kurata, T ^{[1
]}

机构：

[1] KEIO UNIV,SCH MED,DEPT OPHTHALMOL,TOKYO,JAPAN

来源：

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 1997年 / 17卷 / 09期

关键词：

D O I：

10.1089/jir.1997.17.537

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We compared the sensitivity of 19 herpes simplex virus (HSV) strains to type I (IFN-alpha and IFN-beta) and type II (IFN-gamma) human interferons in cultures of human retinal epithelial (K-1034) and lung (HEL) cells, Their sensitivities proved to be well correlated, even though type I and type IT IFN have been reported to have different antiviral actions, The correlation was not because IFN-gamma stimulated the formation of IFN-beta, for an antibody that neutralized IFN-beta did not reduce its inhibitory effects, Our results show that each HSV strain has a characteristic and similar sensitivity to type I and type II IFN and suggest some common pathway in the mechanism of their antiviral actions.

引用

页码：537 / 541

页数：5

共 29 条

[1] ENHANCED INHIBITION OF HERPES-SIMPLEX VIRUS TYPE-1 GROWTH IN HUMAN CORNEAL FIBROBLASTS BY COMBINATIONS OF INTERFERON-ALPHA AND INTERFERON-GAMMA [J].