Emerging functions of BRCA2 in DNA recombination

被引：82

作者：

Pellegrini, L

Venkitaraman, A

机构：

[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England

[2] Univ Cambridge, CR UK Dept Oncol, Cambridge CB2 2XZ, England

[3] Univ Cambridge, MRC, Canc Cell Unit, Cambridge CB2 2XZ, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2004年 / 29卷 / 06期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.tibs.2004.04.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mutations in the breast cancer susceptibility protein BRCA2 cause inherited susceptibility to breast, ovarian and other cancers. There is now compelling experimental evidence that a major biological function of BRCA2 is the maintenance of chromosome structure stability in dividing cells by regulation of steps in recombination between homologous DNA strands. Recent experimental findings shape the current models for BRCA2 function, and structural and biochemical advances shed new light on the interactions between BRCA2, the RAD51 recombinase and single-stranded DNA during DNA recombination.

引用

收藏

页码：310 / 316

页数：7

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