Frequency of silent myocardial ischemia in type 2 diabetic patients and the relation with poor glycemic control

被引:18
作者
Araz, M [1 ]
Celen, Z
Akdemir, I
Okan, V
机构
[1] Gaziantep Univ, Fac Med, Dept Internal Med, TR-27070 Gaziantep, Turkey
[2] Gaziantep Univ, Fac Med, Dept Nucl Med, Gaziantep, Turkey
[3] Gaziantep Univ, Fac Med, Dept Cardiol, Gaziantep, Turkey
关键词
silent myocardial ischemia; type 2 diabetes mellitus; HbA(1c); retinopathy;
D O I
10.1007/s00592-004-0142-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The aim of the study was to investigate the frequency of silent myocardial ischemia in type 2 diabetic patients without any clinical or laboratory findings of myocardial ischemia and to examine the related factors for silent myocardial ischemia. A total of 116 type 2 diabetic patients (82 women) with a disease duration of 5-20 years were included in the study. All patients underwent stress and resting myocardial perfusion single-photon emission computed tomographic (SPECT) study with Tc-99m-MIBI. Coronary angiography was performed in patients with ischemia established at myocardial perfusion SPECT. Ischemia was determined in 18 (15.5%) patients by myocardial perfusion SPECT. Coronary angiography performed in 17 of these patients confirmed coronary stenosis >50% in 11 patients. Thus, the prevalence of silent myocardial ischemia was 9.6%. Significant relations were found between silent myocardial ischemia and male sex, high HbA(1C) level and retinopathy. Type 2 diabetic patients (especially men) with poorly controlled diabetes mellitus or retinopathy should be screened for silent myocardial ischemia.
引用
收藏
页码:38 / 43
页数:6
相关论文
共 40 条
[1]  
[Anonymous], 1997, Am J Cardiol, V79, P134
[2]   Angiotensin-converting enzyme gene polymorphism and microvascular complications in Turkish type 2 diabetic patients [J].
Araz, M ;
Yilmaz, N ;
Güngör, K ;
Okan, V ;
Kepekci, Y ;
Aynacioglu, AS .
DIABETES RESEARCH AND CLINICAL PRACTICE, 2001, 54 (02) :95-104
[3]   PREVALENCE OF SILENT-MYOCARDIAL-ISCHEMIA DETECTED BY 24-HOUR AMBULATORY ELECTROCARDIOGRAPHY, AND ITS ASSOCIATION WITH NEW CORONARY EVENTS AT 40-MONTH FOLLOW-UP IN ELDERLY DIABETIC AND NONDIABETIC PATIENTS WITH CORONARY-ARTERY DISEASE [J].
ARONOW, WS ;
MERCANDO, AD ;
EPSTEIN, S .
AMERICAN JOURNAL OF CARDIOLOGY, 1992, 69 (05) :555-556
[4]   EXERCISE-INDUCED SILENT ISCHEMIA - AGE, DIABETES-MELLITUS, PREVIOUS MYOCARDIAL-INFARCTION AND PROGNOSIS [J].
CALLAHAM, PR ;
FROELICHER, VF ;
KLEIN, J ;
RISCH, M ;
DUBACH, P ;
FRIIS, R .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1989, 14 (05) :1175-1180
[5]   ASYMPTOMATIC TRANSIENT ST CHANGES DURING AMBULATORY ECG MONITORING IN DIABETIC-PATIENTS [J].
CHIARIELLO, M ;
INDOLFI, C ;
COTECCHIA, MR ;
SIFOLA, C ;
ROMANO, M ;
CONDORELLI, M .
AMERICAN HEART JOURNAL, 1985, 110 (03) :529-534
[6]   FREQUENCY OF PAINLESS MYOCARDIAL-ISCHEMIA DURING EXERCISE TOLERANCE TESTING IN PATIENTS WITH AND WITHOUT DIABETES-MELLITUS [J].
CHIPKIN, SR ;
FRID, D ;
ALPERT, JS ;
BAKER, SP ;
DALEN, JE ;
ARONIN, N .
AMERICAN JOURNAL OF CARDIOLOGY, 1987, 59 (01) :61-65
[7]  
CHUNSHENG L, 1993, CHIN MED SCI J, V8, P118
[8]   SILENT MYOCARDIAL ISCHEMIA [J].
COHN, PF .
ANNALS OF INTERNAL MEDICINE, 1988, 109 (04) :312-317
[9]   Prevalence and prognostic value of perfusion defects detected by stress technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography in asymptomatic patients with, diabetes mellitus and no known coronary artery disease [J].
De Lorenzo, A ;
Lima, RSL ;
Siqueira, AG ;
Pantoja, MR .
AMERICAN JOURNAL OF CARDIOLOGY, 2002, 90 (08) :827-832
[10]   Silent myocardial ischaemia in patients with proved coronary artery disease: a comparison of diabetic and non-diabetic patients [J].
Ditchburn, CJ ;
Hall, JA ;
de Belder, M ;
Davies, A ;
Kelly, W ;
Bilous, R .
POSTGRADUATE MEDICAL JOURNAL, 2001, 77 (908) :395-398