Preparation of biocompatible magnetite nanocrystals for in vivo magnetic resonance detection of cancer

被引：403

作者：

Hu, Fengqin

Wei, Li

Zhou, Zhuan

Ran, Yuliang

Li, Zhen

Gao, Mingyuan ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Chem, Key Lab Colloid Interface Sci & Chem Thermodynam, Beijing 100080, Peoples R China

[2] Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China

[3] Chinese Acad Med Sci, Inst Canc, Dept Cell & Mol Biol, Beijing 100021, Peoples R China

[4] Peking Union Med Coll, Beijing 100021, Peoples R China

来源：

ADVANCED MATERIALS | 2006年 / 18卷 / 19期

关键词：

D O I：

10.1002/adma.200600385

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Biocompatible Fe3O4 magnetic nanocrystals with reactive moieties on the surface can be prepared via a "one-pot" reaction and used straightforwardly in cancer detection by being coupled with a specific cancer-targeting antibody. It is demonstrated that the as-prepared Fe3O4 nanocrystals can potentially be used as effective magnetic resonance imaging (MRI) contrast agents for cancer diagnosis (see figure).

引用

页码：2553 / +

页数：5

共 26 条

[1]

[Anonymous], 2000, IRON OXIDES LAB, P5

[2] Functionalisation of magnetic nanoparticles for applications in biomedicine [J].

Berry, CC ;

Curtis, ASG .

JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2003, 36 (13) :R198-R206

[3] MAGNETOFERRITIN - CHARACTERIZATION OF A NOVEL SUPERPARAMAGNETIC MR CONTRAST AGENT [J].

BULTE, JWM ;

DOUGLAS, T ;

MANN, S ;

FRANKEL, RB ;

MOSKOWITZ, BM ;

BROOKS, RA ;

BAUMGARNER, CD ;

VYMAZAL, J ;

STRUB, MP ;

FRANK, JA .

JOURNAL OF MAGNETIC RESONANCE IMAGING, 1994, 4 (03) :497-505

[4] Using biofunctional magnetic nanoparticles to capture vancomycin-resistant enterococci and other gram-positive bacteria at ultralow concentration [J].

Gu, HW ;

Ho, PL ;

Tsang, KWT ;

Wang, L ;

Xu, B .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (51) :15702-15703

[5] Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications [J].

Gupta, AK ;

Gupta, M .

BIOMATERIALS, 2005, 26 (18) :3995-4021

[6]

HU F, UNPUB

[7] In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals [J].

Huh, YM ;

Jun, YW ;

Song, HT ;

Kim, S ;

Choi, JS ;

Lee, JH ;

Yoon, S ;

Kim, KS ;

Shin, JS ;

Suh, JS ;

Cheon, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (35) :12387-12391

[8] Thermotherapy using magnetic nanoparticles combined with external radiation in an orthotopic rat model of prostate cancer [J].

Johannsen, M ;

Thiesen, B ;

Gneveckow, U ;

Taymoorian, K ;

Waldöfner, N ;

Scholz, R ;

Deger, S ;

Jung, K ;

Loening, SA ;

Jordan, A .

PROSTATE, 2006, 66 (01) :97-104

[9] Nanoscale size effect of magnetic nanocrystals and their utilization for cancer diagnosis via magnetic resonance imaging [J].

Jun, YW ;

Huh, YM ;

Choi, JS ;

Lee, JH ;

Song, HT ;

Kim, S ;

Yoon, S ;

Kim, KS ;

Shin, JS ;

Suh, JS ;

Cheon, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (16) :5732-5733

[10] Magnetofection -: A highly efficient tool for antisense oligonucleotide delivery in vitro and in vivo [J].

Krötz, F ;

de Wit, C ;

Sohn, HY ;

Zahler, S ;

Gloe, T ;

Pohl, U ;

Plank, C .

MOLECULAR THERAPY, 2003, 7 (05) :700-710

← 1 2 3 →