Heat shock proteins and arthritis - New readers start here

被引：17

作者：

Gaston, JSH ^{[1
]}

机构：

[1] UNIV CAMBRIDGE, DEPT MED, CAMBRIDGE CB2 1TN, ENGLAND

来源：

AUTOIMMUNITY | 1997年 / 26卷 / 01期

关键词：

heat shock proteins; arthritis; T lymphocytes; tolerance; autoimmunity; immunomodulation;

D O I：

10.3109/08916939709009548

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The possible roles of heat shock proteins in the pathogenesis of inflammatory arthritis have been discussed for a number of years, and investigated intensively in both animal models and human disease. This review surveys evidence which has pointed, on the one hand, to hsp as targets of a pathogenic immune response, and on the other, to an immunoregulatory role for T cell recognition of self hsp, The extent to which findings in experimental animals have led to further insights applicable to human disease is also emphasised.

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收藏

页码：33 / 42

页数：10

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