Genes determining blood cell traits

被引：24

作者：

Andrews, Nancy C. ^{[1
,2
]}

机构：

[1] Duke Univ, Dept Pediat & Pharmacol, Durham, NC 27710 USA

[2] Duke Univ, Dept Canc Biol, Durham, NC USA

来源：

NATURE GENETICS | 2009年 / 41卷 / 11期

关键词：

IRON-DEFICIENCY; TMPRSS6; HEMOJUVELIN; HEMOGLOBIN;

D O I：

10.1038/ng1109-1161

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Four genome-wide association studies report associations to a range of clinically relevant hematological traits. The candidate genes identified include many that are known to be important in iron homeostasis and red blood cell maturation.

引用

页码：1161 / 1162

页数：2

共 15 条

[1] Forging a field: the golden age of iron biology [J].

Andrews, Nancy C. .

BLOOD, 2008, 112 (02) :219-230

[2] Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression [J].

Babitt, JL ;

Huang, FW ;

Wrighting, DM ;

Xia, Y ;

Sidis, Y ;

Samad, TA ;

Campagna, JA ;

Chung, RT ;

Schneyer, AL ;

Woolf, CJ ;

Andrews, NC ;

Lin, HY .

NATURE GENETICS, 2006, 38 (05) :531-539

[3] Screening for hemochromatosis in routine medical care: An evaluation of mean corpuscular volume and mean corpuscular hemoglobin [J].

Barton, JC ;

Bertoli, LF ;

Rothenberg, BE .

GENETIC TESTING, 2000, 4 (02) :103-110

[4] Common variants in TMPRSS6 are associated with iron status and erythrocyte volume [J].

Benyamin, Beben ;

Ferreira, Manuel A. R. ;

Willemsen, Gonneke ;

Gordon, Scott ;

Middelberg, Rita P. S. ;

McEvoy, Brian P. ;

Hottenga, Jouke-Jan ;

Henders, Anjali K. ;

Campbell, Megan J. ;

Wallace, Leanne ;

Frazer, Ian H. ;

Heath, Andrew C. ;

de Geus, Eco J. C. ;

Nyholt, Dale R. ;

Visscher, Peter M. ;

Penninx, Brenda W. ;

Boomsma, Dorret I. ;

Martin, Nicholas G. ;

Montgomery, Grant W. ;

Whitfield, John B. .

NATURE GENETICS, 2009, 41 (11) :1173-1175

[5] Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels [J].

Chambers, John C. ;

Zhang, Weihua ;

Li, Yun ;

Sehmi, Joban ;

Wass, Mark N. ;

Zabaneh, Delilah ;

Hoggart, Clive ;

Bayele, Henry ;

McCarthy, Mark I. ;

Peltonen, Leena ;

Freimer, Nelson B. ;

Srai, Surjit K. ;

Maxwell, Patrick H. ;

Sternberg, Michael J. E. ;

Ruokonen, Aimo ;

Abecasis, Goncalo ;

Jarvelin, Marjo-Riitta ;

Scott, James ;

Elliott, Paul ;

Kooner, Jaspal S. .

NATURE GENETICS, 2009, 41 (11) :1170-1172

[6] The serine protease TMPRSS6 is required to sense iron deficiency [J].

Du, Xin ;

She, Ellen ;

Gelbart, Terri ;

Truksa, Jaroslav ;

Lee, Pauline ;

Xia, Yu ;

Khovananth, Kevin ;

Mudd, Suzanne ;

Mann, Navjiwan ;

Moresco, Eva Marie Y. ;

Beutler, Ernest ;

Beutler, Bruce .

SCIENCE, 2008, 320 (5879) :1088-1092

[7] Major quantitative trait locus for eosinophil count is located on chromosome 2q [J].

Evans, DM ;

Zhu, G ;

Duffy, DL ;

Montgomery, GW ;

Frazer, IH ;

Martin, NG .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2004, 114 (04) :826-830

[8] Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA) [J].

Finberg, Karin E. ;

Heeney, Matthew M. ;

Campagna, Dean R. ;

Aydinok, Yesim ;

Pearson, Howard A. ;

Hartman, Kip R. ;

Mayo, Mary M. ;

Samuel, Stewart M. ;

Strouse, John J. ;

Markianos, Kyriacos ;

Andrews, Nancy C. ;

Fleming, Mark D. .

NATURE GENETICS, 2008, 40 (05) :569-571

[9] Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium [J].

Ganesh, Santhi K. ;

Zakai, Neil A. ;

van Rooij, Frank J. A. ;

Soranzo, Nicole ;

Smith, Albert V. ;

Nalls, Michael A. ;

Chen, Ming-Huei ;

Kottgen, Anna ;

Glazer, Nicole L. ;

Dehghan, Abbas ;

Kuhnel, Brigitte ;

Aspelund, Thor ;

Yang, Qiong ;

Tanaka, Toshiko ;

Jaffe, Andrew ;

Bis, Joshua C. M. ;

Verwoert, Germaine C. ;

Teumer, Alexander ;

Fox, Caroline S. ;

Guralnik, Jack M. ;

Ehret, Georg B. ;

Rice, Kenneth ;

Felix, Janine F. ;

Rendon, Augusto ;

Eiriksdottir, Gudny ;

Levy, Daniel ;

Patel, Kushang V. ;

Boerwinkle, Eric ;

Rotter, Jerome I. ;

Hofman, Albert ;

Sambrook, Jennifer G. ;

Hernandez, Dena G. ;

Zheng, Gang ;

Bandinelli, Stefania ;

Singleton, Andrew B. ;

Coresh, Josef ;

Lumley, Thomas ;

Uitterlinden, Andre G. ;

vanGils, Janine M. ;

Launer, Lenore J. ;

Cupples, L. Adrienne ;

Oostra, Ben A. ;

Zwaginga, Jaap-Jan ;

Ouwehand, Willem H. ;

Thein, Swee-Lay ;

Meisinger, Christa ;

Deloukas, Panos ;

Nauck, Matthias ;

Spector, Tim D. ;

Gieger, Christian .

NATURE GENETICS, 2009, 41 (11) :1191-U48

[10] Historical review: megakaryopoiesis and thrombopoiesis [J].

Kaushansky, Kenneth .

BLOOD, 2008, 111 (03) :981-986

← 1 2 →